LncRNA TP73-AS1 down-regulates miR-139-3p to promote retinoblastoma cell proliferation

Our study aimed to investigate the role of long non-coding RNAs (lncRNA) TP73-AS1 in retinoblastoma (Rb). In the present study, we found that TP73-AS1 was up-regulated, while miR-139–3p was down-regulated in Rb. TP73-AS1 and miR-139-3p were inversely correlated in Rb tissues. In cells of Rb cell lin...

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Detalles Bibliográficos
Autores principales: Xia, Zhaoxia, Yang, Xiaoxi, Wu, Shuduan, Feng, Zhizhen, Qu, Lei, Chen, Xianghua, Liu, Linyu, Ma, Yanling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509052/
https://www.ncbi.nlm.nih.gov/pubmed/31015368
http://dx.doi.org/10.1042/BSR20190475
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author Xia, Zhaoxia
Yang, Xiaoxi
Wu, Shuduan
Feng, Zhizhen
Qu, Lei
Chen, Xianghua
Liu, Linyu
Ma, Yanling
author_facet Xia, Zhaoxia
Yang, Xiaoxi
Wu, Shuduan
Feng, Zhizhen
Qu, Lei
Chen, Xianghua
Liu, Linyu
Ma, Yanling
author_sort Xia, Zhaoxia
collection PubMed
description Our study aimed to investigate the role of long non-coding RNAs (lncRNA) TP73-AS1 in retinoblastoma (Rb). In the present study, we found that TP73-AS1 was up-regulated, while miR-139–3p was down-regulated in Rb. TP73-AS1 and miR-139-3p were inversely correlated in Rb tissues. In cells of Rb cell lines, overexpression of miR-139-3p failed to affect TP73-AS1, while TP73-AS1 overexpression caused the down-regulated miR-139-3p. TP73-AS1 overexpression caused promoted proliferation of Rb cells but showed no significant effects on cell migration and invasion. miR-139-3p overexpression played an opposite role and attenuated the effects of TP73-AS1 overexpression. Therefore, lncRNA TP73-AS1 may down-regulate miR-139-3p to promote Rb cell proliferation.
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spelling pubmed-65090522019-05-20 LncRNA TP73-AS1 down-regulates miR-139-3p to promote retinoblastoma cell proliferation Xia, Zhaoxia Yang, Xiaoxi Wu, Shuduan Feng, Zhizhen Qu, Lei Chen, Xianghua Liu, Linyu Ma, Yanling Biosci Rep Research Articles Our study aimed to investigate the role of long non-coding RNAs (lncRNA) TP73-AS1 in retinoblastoma (Rb). In the present study, we found that TP73-AS1 was up-regulated, while miR-139–3p was down-regulated in Rb. TP73-AS1 and miR-139-3p were inversely correlated in Rb tissues. In cells of Rb cell lines, overexpression of miR-139-3p failed to affect TP73-AS1, while TP73-AS1 overexpression caused the down-regulated miR-139-3p. TP73-AS1 overexpression caused promoted proliferation of Rb cells but showed no significant effects on cell migration and invasion. miR-139-3p overexpression played an opposite role and attenuated the effects of TP73-AS1 overexpression. Therefore, lncRNA TP73-AS1 may down-regulate miR-139-3p to promote Rb cell proliferation. Portland Press Ltd. 2019-05-10 /pmc/articles/PMC6509052/ /pubmed/31015368 http://dx.doi.org/10.1042/BSR20190475 Text en © 2019 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Xia, Zhaoxia
Yang, Xiaoxi
Wu, Shuduan
Feng, Zhizhen
Qu, Lei
Chen, Xianghua
Liu, Linyu
Ma, Yanling
LncRNA TP73-AS1 down-regulates miR-139-3p to promote retinoblastoma cell proliferation
title LncRNA TP73-AS1 down-regulates miR-139-3p to promote retinoblastoma cell proliferation
title_full LncRNA TP73-AS1 down-regulates miR-139-3p to promote retinoblastoma cell proliferation
title_fullStr LncRNA TP73-AS1 down-regulates miR-139-3p to promote retinoblastoma cell proliferation
title_full_unstemmed LncRNA TP73-AS1 down-regulates miR-139-3p to promote retinoblastoma cell proliferation
title_short LncRNA TP73-AS1 down-regulates miR-139-3p to promote retinoblastoma cell proliferation
title_sort lncrna tp73-as1 down-regulates mir-139-3p to promote retinoblastoma cell proliferation
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509052/
https://www.ncbi.nlm.nih.gov/pubmed/31015368
http://dx.doi.org/10.1042/BSR20190475
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