L-securinine inhibits cell growth and metastasis of human androgen-independent prostate cancer DU145 cells via regulating mitochondrial and AGTR1/MEK/ERK/STAT3/PAX2 apoptotic pathways

The present study aims to evaluate the anticancer effect of L-securinine on androgen-independent prostate cancer (AIPC) DU145 cells. L-securinine (2.5, 5, and 10 μM) treatment for 24, 48 and 72 h displayed strong growth inhibitory effect on DU145 cells in a concentration and time-dependent fashion b...

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Detalles Bibliográficos
Autores principales: Zhang, Dongxu, Liu, Houxian, Yang, Binbin, Hu, Jiasheng, Cheng, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509055/
https://www.ncbi.nlm.nih.gov/pubmed/30975734
http://dx.doi.org/10.1042/BSR20190469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509055/
https://www.ncbi.nlm.nih.gov/pubmed/30975734
http://dx.doi.org/10.1042/BSR20190469

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