Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism

Biological roles of obscurin and its close homolog Obsl1 (obscurin-like 1) have been enigmatic. While obscurin is highly expressed in striated muscles, Obsl1 is found ubiquitously. Accordingly, obscurin mutations have been linked to myopathies, whereas mutations in Obsl1 result in 3M-growth syndrome...

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Detalles Bibliográficos
Autores principales: Blondelle, Jordan, Marrocco, Valeria, Clark, Madison, Desmond, Patrick, Myers, Stephanie, Nguyen, Jim, Wright, Matthew, Bremner, Shannon, Pierantozzi, Enrico, Ward, Samuel, Estève, Eric, Sorrentino, Vincenzo, Ghassemian, Majid, Lange, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509138/
https://www.ncbi.nlm.nih.gov/pubmed/31098411
http://dx.doi.org/10.1038/s42003-019-0405-7

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