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Association Between Connectivity of Hippocampal Sub-Regions and Auditory Verbal Hallucinations in Schizophrenia

Background: Hippocampal dysconnectivity has been detected in schizophrenia patients with auditory verbal hallucinations (AVHs). Neuroanatomical evidence has indicated distinct sub-regions in the hippocampus, but which sub-regions within the hippocampus may emerge dysfunction in the brain network, an...

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Autores principales: Liu, Lin, Cui, Long-Biao, Xi, Yi-Bin, Wang, Xing-Rui, Liu, Yu-Chen, Xu, Zi-Liang, Wang, Hua-Ning, Yin, Hong, Qin, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509236/
https://www.ncbi.nlm.nih.gov/pubmed/31130837
http://dx.doi.org/10.3389/fnins.2019.00424
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author Liu, Lin
Cui, Long-Biao
Xi, Yi-Bin
Wang, Xing-Rui
Liu, Yu-Chen
Xu, Zi-Liang
Wang, Hua-Ning
Yin, Hong
Qin, Wei
author_facet Liu, Lin
Cui, Long-Biao
Xi, Yi-Bin
Wang, Xing-Rui
Liu, Yu-Chen
Xu, Zi-Liang
Wang, Hua-Ning
Yin, Hong
Qin, Wei
author_sort Liu, Lin
collection PubMed
description Background: Hippocampal dysconnectivity has been detected in schizophrenia patients with auditory verbal hallucinations (AVHs). Neuroanatomical evidence has indicated distinct sub-regions in the hippocampus, but which sub-regions within the hippocampus may emerge dysfunction in the brain network, and the relationship between connection strength and the severity of this debilitating disorder have yet to be revealed. Masked independent component analysis (mICA), i.e., ICA restricted to a defined region of interest, can provide insight into observing local functional connectivity in a particular brain region. We aim to map out the sub-regions in the hippocampus with dysconnectivity linked to AVHs in schizophrenia. Methods: In this functional magnetic resonance imaging study of schizophrenia patients with (n = 57) and without (n = 83) AVHs, and 71 healthy controls, we first examined hippocampal connectivity using mICA, and then the correlation between connection metric and clinical severity was generated. Results: As compared with patients without AVHs, mICA showed a group of hyper-connections for the left middle part, as well as another group of hypo-connections for the bilateral antero-lateral and right antero-medial parts in patients with AVHs. Connectivity was linked to the clinical symptoms scores in the sample of patients with AVHs. Conclusion: These findings demonstrate that the left middle part is more densely connected, but the bilateral antero-lateral and right antero-medial parts are more sparsely connected in schizophrenia patients with AVHs. The findings in the present study show proof of precious location in the hippocampus mediating the neural mechanism behind AVHs in schizophrenia.
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spelling pubmed-65092362019-05-24 Association Between Connectivity of Hippocampal Sub-Regions and Auditory Verbal Hallucinations in Schizophrenia Liu, Lin Cui, Long-Biao Xi, Yi-Bin Wang, Xing-Rui Liu, Yu-Chen Xu, Zi-Liang Wang, Hua-Ning Yin, Hong Qin, Wei Front Neurosci Neuroscience Background: Hippocampal dysconnectivity has been detected in schizophrenia patients with auditory verbal hallucinations (AVHs). Neuroanatomical evidence has indicated distinct sub-regions in the hippocampus, but which sub-regions within the hippocampus may emerge dysfunction in the brain network, and the relationship between connection strength and the severity of this debilitating disorder have yet to be revealed. Masked independent component analysis (mICA), i.e., ICA restricted to a defined region of interest, can provide insight into observing local functional connectivity in a particular brain region. We aim to map out the sub-regions in the hippocampus with dysconnectivity linked to AVHs in schizophrenia. Methods: In this functional magnetic resonance imaging study of schizophrenia patients with (n = 57) and without (n = 83) AVHs, and 71 healthy controls, we first examined hippocampal connectivity using mICA, and then the correlation between connection metric and clinical severity was generated. Results: As compared with patients without AVHs, mICA showed a group of hyper-connections for the left middle part, as well as another group of hypo-connections for the bilateral antero-lateral and right antero-medial parts in patients with AVHs. Connectivity was linked to the clinical symptoms scores in the sample of patients with AVHs. Conclusion: These findings demonstrate that the left middle part is more densely connected, but the bilateral antero-lateral and right antero-medial parts are more sparsely connected in schizophrenia patients with AVHs. The findings in the present study show proof of precious location in the hippocampus mediating the neural mechanism behind AVHs in schizophrenia. Frontiers Media S.A. 2019-05-03 /pmc/articles/PMC6509236/ /pubmed/31130837 http://dx.doi.org/10.3389/fnins.2019.00424 Text en Copyright © 2019 Liu, Cui, Xi, Wang, Liu, Xu, Wang, Yin and Qin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Liu, Lin
Cui, Long-Biao
Xi, Yi-Bin
Wang, Xing-Rui
Liu, Yu-Chen
Xu, Zi-Liang
Wang, Hua-Ning
Yin, Hong
Qin, Wei
Association Between Connectivity of Hippocampal Sub-Regions and Auditory Verbal Hallucinations in Schizophrenia
title Association Between Connectivity of Hippocampal Sub-Regions and Auditory Verbal Hallucinations in Schizophrenia
title_full Association Between Connectivity of Hippocampal Sub-Regions and Auditory Verbal Hallucinations in Schizophrenia
title_fullStr Association Between Connectivity of Hippocampal Sub-Regions and Auditory Verbal Hallucinations in Schizophrenia
title_full_unstemmed Association Between Connectivity of Hippocampal Sub-Regions and Auditory Verbal Hallucinations in Schizophrenia
title_short Association Between Connectivity of Hippocampal Sub-Regions and Auditory Verbal Hallucinations in Schizophrenia
title_sort association between connectivity of hippocampal sub-regions and auditory verbal hallucinations in schizophrenia
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509236/
https://www.ncbi.nlm.nih.gov/pubmed/31130837
http://dx.doi.org/10.3389/fnins.2019.00424
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