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De novo aggregation of Alzheimer’s Aβ25-35 peptides in a lipid bilayer
A potential mechanism of cytotoxicity attributed to Alzheimer’s Aβ peptides postulates that their aggregation disrupts membrane structure causing uncontrollable permeation of Ca(2+) ions. To gain molecular insights into these processes, we have performed all-atom explicit solvent replica exchange wi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509337/ https://www.ncbi.nlm.nih.gov/pubmed/31073226 http://dx.doi.org/10.1038/s41598-019-43685-7 |