Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Transition from Naive Pluripotency

The gene regulatory network (GRN) of naive mouse embryonic stem cells (ESCs) must be reconfigured to enable lineage commitment. TCF3 sanctions rewiring by suppressing components of the ESC transcription factor circuitry. However, TCF3 depletion only delays and does not prevent transition to formativ...

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Detalles Bibliográficos
Autores principales: Kalkan, Tüzer, Bornelöv, Susanne, Mulas, Carla, Diamanti, Evangelia, Lohoff, Tim, Ralser, Meryem, Middelkamp, Sjors, Lombard, Patrick, Nichols, Jennifer, Smith, Austin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509416/
https://www.ncbi.nlm.nih.gov/pubmed/31031137
http://dx.doi.org/10.1016/j.stem.2019.03.017

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