Cargando…
Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets
The toolkit for repairing damaged neurons in amyotrophic lateral sclerosis (ALS) and spinal cord injury (SCI) is extremely limited. Here, we reviewed the in vitro and in vivo studies and clinical trials on nonneuronal cells in the neurodegenerative processes common to both these conditions. Special...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Croatian Medical Schools
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509626/ https://www.ncbi.nlm.nih.gov/pubmed/31044582 http://dx.doi.org/10.3325/cmj.2019.60.109 |
_version_ | 1783417281873707008 |
---|---|
author | Ban, Jelena Sámano, Cynthia Mladinic, Miranda Munitic, Ivana |
author_facet | Ban, Jelena Sámano, Cynthia Mladinic, Miranda Munitic, Ivana |
author_sort | Ban, Jelena |
collection | PubMed |
description | The toolkit for repairing damaged neurons in amyotrophic lateral sclerosis (ALS) and spinal cord injury (SCI) is extremely limited. Here, we reviewed the in vitro and in vivo studies and clinical trials on nonneuronal cells in the neurodegenerative processes common to both these conditions. Special focus was directed to microglia and astrocytes, because their activation and proliferation, also known as neuroinflammation, is a key driver of neurodegeneration. Neuroinflammation is a multifaceted process that evolves during the disease course, and can be either beneficial or toxic to neurons. Given the fundamental regulatory functions of glia, pathogenic mechanisms in neuroinflammation represent promising therapeutic targets. We also discussed neuroprotective, immunosuppressive, and stem-cell based approaches applicable to both ALS and SCI. |
format | Online Article Text |
id | pubmed-6509626 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Croatian Medical Schools |
record_format | MEDLINE/PubMed |
spelling | pubmed-65096262019-05-17 Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets Ban, Jelena Sámano, Cynthia Mladinic, Miranda Munitic, Ivana Croat Med J International Conference on Neurological Disorders and Neurorestoration The toolkit for repairing damaged neurons in amyotrophic lateral sclerosis (ALS) and spinal cord injury (SCI) is extremely limited. Here, we reviewed the in vitro and in vivo studies and clinical trials on nonneuronal cells in the neurodegenerative processes common to both these conditions. Special focus was directed to microglia and astrocytes, because their activation and proliferation, also known as neuroinflammation, is a key driver of neurodegeneration. Neuroinflammation is a multifaceted process that evolves during the disease course, and can be either beneficial or toxic to neurons. Given the fundamental regulatory functions of glia, pathogenic mechanisms in neuroinflammation represent promising therapeutic targets. We also discussed neuroprotective, immunosuppressive, and stem-cell based approaches applicable to both ALS and SCI. Croatian Medical Schools 2019-04 /pmc/articles/PMC6509626/ /pubmed/31044582 http://dx.doi.org/10.3325/cmj.2019.60.109 Text en Copyright © 2019 by the Croatian Medical Journal. All rights reserved. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | International Conference on Neurological Disorders and Neurorestoration Ban, Jelena Sámano, Cynthia Mladinic, Miranda Munitic, Ivana Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets |
title | Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets |
title_full | Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets |
title_fullStr | Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets |
title_full_unstemmed | Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets |
title_short | Glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets |
title_sort | glia in amyotrophic lateral sclerosis and spinal cord injury: common therapeutic targets |
topic | International Conference on Neurological Disorders and Neurorestoration |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509626/ https://www.ncbi.nlm.nih.gov/pubmed/31044582 http://dx.doi.org/10.3325/cmj.2019.60.109 |
work_keys_str_mv | AT banjelena gliainamyotrophiclateralsclerosisandspinalcordinjurycommontherapeutictargets AT samanocynthia gliainamyotrophiclateralsclerosisandspinalcordinjurycommontherapeutictargets AT mladinicmiranda gliainamyotrophiclateralsclerosisandspinalcordinjurycommontherapeutictargets AT muniticivana gliainamyotrophiclateralsclerosisandspinalcordinjurycommontherapeutictargets |