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Changes of serum 25(OH) D3 and IGF-1 levels in patients with thyroid nodules
BACKGROUND: The present study aimed to study the relationship between serum 25 hydroxyvitamin D3(25(OH)D3) and insulin-like growth factor-1 (IGF-1) and thyroid nodules. METHODS: Two hundred eighty-nine cases with thyroid nodules and 109 health subjects (control group) who admitted to the Hebei Gener...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509827/ https://www.ncbi.nlm.nih.gov/pubmed/31077177 http://dx.doi.org/10.1186/s12902-019-0376-1 |
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author | Du, Xueqin Liu, Yi Zhao, Chunhui Fang, Jingzhou Wang, Xiangna Wei, Limin |
author_facet | Du, Xueqin Liu, Yi Zhao, Chunhui Fang, Jingzhou Wang, Xiangna Wei, Limin |
author_sort | Du, Xueqin |
collection | PubMed |
description | BACKGROUND: The present study aimed to study the relationship between serum 25 hydroxyvitamin D3(25(OH)D3) and insulin-like growth factor-1 (IGF-1) and thyroid nodules. METHODS: Two hundred eighty-nine cases with thyroid nodules and 109 health subjects (control group) who admitted to the Hebei General Hospital during June 2016 to December 2016 were included in the study. Basic clinical information (age, sex, thyroid function, liver and kidney function, hypertension history, etc.) of patients were collected. Serum 25(OH) D3 and Serum IGF-1 were detected by electrochemiluminescence and radioimmunoassay methods, respectively. The relationship between the above-mentioned factors and thyroid nodules was statistically analyzed. RESULTS: Serum 25(OH)D3, IGF-1, fasting blood glucose (FBG), total cholesterol (TC), waist circumference (WC), total triiodothyronine (TT3), total thyroxine (TT4), hypertension history, and drinking history were significantly different between the nodules group and the control group (P < 0.05). Logistic regression analysis showed that there was a negative correlation between thyroid nodules and levels of 25(OH)D3, IGF-1, TT3, as well as a positive correlation with FBG, TC, TT4, and hypertension. There was a positive correlation between IGF-1 and serum 25(OH)D3 in thyroid nodules (P < 0.05). After correcting the aforementioned factors, high-level of serum 25(OH)D3 was significantly correlated with the decreased incidence of thyroid nodules. CONCLUSIONS: The incidence of thyroid nodules is relatively lower in a high-level of serum 25(OH)D3, and serum 25(OH)D3 may be a direct protective factor for thyroid nodules. Serum IGF-1 can be one of the indirect protective factors for thyroid nodules as well. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12902-019-0376-1) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6509827 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-65098272019-06-05 Changes of serum 25(OH) D3 and IGF-1 levels in patients with thyroid nodules Du, Xueqin Liu, Yi Zhao, Chunhui Fang, Jingzhou Wang, Xiangna Wei, Limin BMC Endocr Disord Research Article BACKGROUND: The present study aimed to study the relationship between serum 25 hydroxyvitamin D3(25(OH)D3) and insulin-like growth factor-1 (IGF-1) and thyroid nodules. METHODS: Two hundred eighty-nine cases with thyroid nodules and 109 health subjects (control group) who admitted to the Hebei General Hospital during June 2016 to December 2016 were included in the study. Basic clinical information (age, sex, thyroid function, liver and kidney function, hypertension history, etc.) of patients were collected. Serum 25(OH) D3 and Serum IGF-1 were detected by electrochemiluminescence and radioimmunoassay methods, respectively. The relationship between the above-mentioned factors and thyroid nodules was statistically analyzed. RESULTS: Serum 25(OH)D3, IGF-1, fasting blood glucose (FBG), total cholesterol (TC), waist circumference (WC), total triiodothyronine (TT3), total thyroxine (TT4), hypertension history, and drinking history were significantly different between the nodules group and the control group (P < 0.05). Logistic regression analysis showed that there was a negative correlation between thyroid nodules and levels of 25(OH)D3, IGF-1, TT3, as well as a positive correlation with FBG, TC, TT4, and hypertension. There was a positive correlation between IGF-1 and serum 25(OH)D3 in thyroid nodules (P < 0.05). After correcting the aforementioned factors, high-level of serum 25(OH)D3 was significantly correlated with the decreased incidence of thyroid nodules. CONCLUSIONS: The incidence of thyroid nodules is relatively lower in a high-level of serum 25(OH)D3, and serum 25(OH)D3 may be a direct protective factor for thyroid nodules. Serum IGF-1 can be one of the indirect protective factors for thyroid nodules as well. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12902-019-0376-1) contains supplementary material, which is available to authorized users. BioMed Central 2019-05-10 /pmc/articles/PMC6509827/ /pubmed/31077177 http://dx.doi.org/10.1186/s12902-019-0376-1 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Du, Xueqin Liu, Yi Zhao, Chunhui Fang, Jingzhou Wang, Xiangna Wei, Limin Changes of serum 25(OH) D3 and IGF-1 levels in patients with thyroid nodules |
title | Changes of serum 25(OH) D3 and IGF-1 levels in patients with thyroid nodules |
title_full | Changes of serum 25(OH) D3 and IGF-1 levels in patients with thyroid nodules |
title_fullStr | Changes of serum 25(OH) D3 and IGF-1 levels in patients with thyroid nodules |
title_full_unstemmed | Changes of serum 25(OH) D3 and IGF-1 levels in patients with thyroid nodules |
title_short | Changes of serum 25(OH) D3 and IGF-1 levels in patients with thyroid nodules |
title_sort | changes of serum 25(oh) d3 and igf-1 levels in patients with thyroid nodules |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509827/ https://www.ncbi.nlm.nih.gov/pubmed/31077177 http://dx.doi.org/10.1186/s12902-019-0376-1 |
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