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Efficient reduction of synthetic mRNA induced immune activation by simultaneous delivery of B18R encoding mRNA
The application of synthetic modified messenger RNA (mRNA) is a promising approach for the treatment of a variety of diseases and vaccination. In the past few years, different modifications of synthetic mRNA were applied to render the mRNA more stable and less immunogenic. However, the repeated appl...
Autores principales: | Michel, Tatjana, Golombek, Sonia, Steinle, Heidrun, Hann, Ludmilla, Velic, Ana, Macek, Boris, Krajewski, Stefanie, Schlensak, Christian, Wendel, Hans Peter, Avci-Adali, Meltem |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509845/ https://www.ncbi.nlm.nih.gov/pubmed/31168319 http://dx.doi.org/10.1186/s13036-019-0172-5 |
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