Multiscale modeling reveals angiogenesis-induced drug resistance in brain tumors and predicts a synergistic drug combination targeting EGFR and VEGFR pathways

BACKGROUND: Experimental studies have demonstrated that both the extracellular vasculature or microenvironment and intracellular molecular network (e.g., epidermal growth factor receptor (EGFR) signaling pathway) are important for brain tumor growth. Additionally, some drugs have been developed to i...

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Detalles Bibliográficos
Autores principales: Liang, Weishan, Zheng, Yongjiang, Zhang, Ji, Sun, Xiaoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509865/
https://www.ncbi.nlm.nih.gov/pubmed/31074391
http://dx.doi.org/10.1186/s12859-019-2737-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509865/
https://www.ncbi.nlm.nih.gov/pubmed/31074391
http://dx.doi.org/10.1186/s12859-019-2737-1

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