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The cis-trans binding strength defined by motif frequencies facilitates statistical inference of transcriptional regulation

BACKGROUND: A key problem in systems biology is the determination of the regulatory mechanism corresponding to a phenotype. An empirical approach in this regard is to compare the expression profiles of cells under two conditions or tissues from two phenotypes and to unravel the underlying transcript...

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Detalles Bibliográficos
Autores principales: Feng, Yance, Zhang, Sheng, Li, Liang, Li, Lei M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509875/
https://www.ncbi.nlm.nih.gov/pubmed/31074378
http://dx.doi.org/10.1186/s12859-019-2732-6