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Elevated Plasma Homocysteine Levels in Anti-N-methyl-D-aspartate Receptor Encephalitis

Objective: Homocysteine (Hcy) levels have been investigated in many diseases, such as neurodegenerative and autoimmune diseases. However, changes in Hcy levels in anti-N-Methyl-D-aspartate receptor (anti-NMDAR) encephalitis have not been investigated thus far. Methods: Case data were collected from...

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Autores principales: Liu, Lizhi, Liang, Jie, Liu, Qing, Luo, Chongliang, Liu, Jia, Fan, Rong, Chen, Zhigang, Chen, Yong, Peng, Fuhua, Jiang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509947/
https://www.ncbi.nlm.nih.gov/pubmed/31130913
http://dx.doi.org/10.3389/fneur.2019.00464
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author Liu, Lizhi
Liang, Jie
Liu, Qing
Luo, Chongliang
Liu, Jia
Fan, Rong
Chen, Zhigang
Chen, Yong
Peng, Fuhua
Jiang, Ying
author_facet Liu, Lizhi
Liang, Jie
Liu, Qing
Luo, Chongliang
Liu, Jia
Fan, Rong
Chen, Zhigang
Chen, Yong
Peng, Fuhua
Jiang, Ying
author_sort Liu, Lizhi
collection PubMed
description Objective: Homocysteine (Hcy) levels have been investigated in many diseases, such as neurodegenerative and autoimmune diseases. However, changes in Hcy levels in anti-N-Methyl-D-aspartate receptor (anti-NMDAR) encephalitis have not been investigated thus far. Methods: Case data were collected from 45 patients with anti-NMDAR encephalitis and 179 age- and sex-matched healthy controls (HCs). Clinical characteristics, Hcy levels, C reactive protein (CRP) levels, and cerebrospinal fluid (CSF) parameters were determined. Association of Hcy and clinical parameters were evaluated in these patients. Among these 45 patients, 15 had a follow-up evaluation at 3 months after treatment. Results: Hcy levels (p < 0.001) and CRP levels (p = 0.005) from the patients with anti-NMDAR encephalitis were significantly higher than those from HCs. Hcy levels from male patients were significantly lower than those from male HCs (p < 0.001). Comparing anti-NMDAR encephalitis patients after treatment with before treatment, the former has significantly higher Hcy levels (p = 0.004), CRP levels (p = 0.041) and mRS scores (p = 0.002). Furthermore, a significant negative correlation between the changes in Hcy levels and the changes in mRS scores (r = −0.534, p = 0.040) was observed. Conclusion: Elevated plasma homocysteine occurs in anti-NMDAR encephalitis, and seems associated with male sex.
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spelling pubmed-65099472019-05-24 Elevated Plasma Homocysteine Levels in Anti-N-methyl-D-aspartate Receptor Encephalitis Liu, Lizhi Liang, Jie Liu, Qing Luo, Chongliang Liu, Jia Fan, Rong Chen, Zhigang Chen, Yong Peng, Fuhua Jiang, Ying Front Neurol Neurology Objective: Homocysteine (Hcy) levels have been investigated in many diseases, such as neurodegenerative and autoimmune diseases. However, changes in Hcy levels in anti-N-Methyl-D-aspartate receptor (anti-NMDAR) encephalitis have not been investigated thus far. Methods: Case data were collected from 45 patients with anti-NMDAR encephalitis and 179 age- and sex-matched healthy controls (HCs). Clinical characteristics, Hcy levels, C reactive protein (CRP) levels, and cerebrospinal fluid (CSF) parameters were determined. Association of Hcy and clinical parameters were evaluated in these patients. Among these 45 patients, 15 had a follow-up evaluation at 3 months after treatment. Results: Hcy levels (p < 0.001) and CRP levels (p = 0.005) from the patients with anti-NMDAR encephalitis were significantly higher than those from HCs. Hcy levels from male patients were significantly lower than those from male HCs (p < 0.001). Comparing anti-NMDAR encephalitis patients after treatment with before treatment, the former has significantly higher Hcy levels (p = 0.004), CRP levels (p = 0.041) and mRS scores (p = 0.002). Furthermore, a significant negative correlation between the changes in Hcy levels and the changes in mRS scores (r = −0.534, p = 0.040) was observed. Conclusion: Elevated plasma homocysteine occurs in anti-NMDAR encephalitis, and seems associated with male sex. Frontiers Media S.A. 2019-05-03 /pmc/articles/PMC6509947/ /pubmed/31130913 http://dx.doi.org/10.3389/fneur.2019.00464 Text en Copyright © 2019 Liu, Liang, Liu, Luo, Liu, Fan, Chen, Chen, Peng and Jiang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Liu, Lizhi
Liang, Jie
Liu, Qing
Luo, Chongliang
Liu, Jia
Fan, Rong
Chen, Zhigang
Chen, Yong
Peng, Fuhua
Jiang, Ying
Elevated Plasma Homocysteine Levels in Anti-N-methyl-D-aspartate Receptor Encephalitis
title Elevated Plasma Homocysteine Levels in Anti-N-methyl-D-aspartate Receptor Encephalitis
title_full Elevated Plasma Homocysteine Levels in Anti-N-methyl-D-aspartate Receptor Encephalitis
title_fullStr Elevated Plasma Homocysteine Levels in Anti-N-methyl-D-aspartate Receptor Encephalitis
title_full_unstemmed Elevated Plasma Homocysteine Levels in Anti-N-methyl-D-aspartate Receptor Encephalitis
title_short Elevated Plasma Homocysteine Levels in Anti-N-methyl-D-aspartate Receptor Encephalitis
title_sort elevated plasma homocysteine levels in anti-n-methyl-d-aspartate receptor encephalitis
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509947/
https://www.ncbi.nlm.nih.gov/pubmed/31130913
http://dx.doi.org/10.3389/fneur.2019.00464
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