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Elevated Plasma Homocysteine Levels in Anti-N-methyl-D-aspartate Receptor Encephalitis
Objective: Homocysteine (Hcy) levels have been investigated in many diseases, such as neurodegenerative and autoimmune diseases. However, changes in Hcy levels in anti-N-Methyl-D-aspartate receptor (anti-NMDAR) encephalitis have not been investigated thus far. Methods: Case data were collected from...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509947/ https://www.ncbi.nlm.nih.gov/pubmed/31130913 http://dx.doi.org/10.3389/fneur.2019.00464 |
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author | Liu, Lizhi Liang, Jie Liu, Qing Luo, Chongliang Liu, Jia Fan, Rong Chen, Zhigang Chen, Yong Peng, Fuhua Jiang, Ying |
author_facet | Liu, Lizhi Liang, Jie Liu, Qing Luo, Chongliang Liu, Jia Fan, Rong Chen, Zhigang Chen, Yong Peng, Fuhua Jiang, Ying |
author_sort | Liu, Lizhi |
collection | PubMed |
description | Objective: Homocysteine (Hcy) levels have been investigated in many diseases, such as neurodegenerative and autoimmune diseases. However, changes in Hcy levels in anti-N-Methyl-D-aspartate receptor (anti-NMDAR) encephalitis have not been investigated thus far. Methods: Case data were collected from 45 patients with anti-NMDAR encephalitis and 179 age- and sex-matched healthy controls (HCs). Clinical characteristics, Hcy levels, C reactive protein (CRP) levels, and cerebrospinal fluid (CSF) parameters were determined. Association of Hcy and clinical parameters were evaluated in these patients. Among these 45 patients, 15 had a follow-up evaluation at 3 months after treatment. Results: Hcy levels (p < 0.001) and CRP levels (p = 0.005) from the patients with anti-NMDAR encephalitis were significantly higher than those from HCs. Hcy levels from male patients were significantly lower than those from male HCs (p < 0.001). Comparing anti-NMDAR encephalitis patients after treatment with before treatment, the former has significantly higher Hcy levels (p = 0.004), CRP levels (p = 0.041) and mRS scores (p = 0.002). Furthermore, a significant negative correlation between the changes in Hcy levels and the changes in mRS scores (r = −0.534, p = 0.040) was observed. Conclusion: Elevated plasma homocysteine occurs in anti-NMDAR encephalitis, and seems associated with male sex. |
format | Online Article Text |
id | pubmed-6509947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65099472019-05-24 Elevated Plasma Homocysteine Levels in Anti-N-methyl-D-aspartate Receptor Encephalitis Liu, Lizhi Liang, Jie Liu, Qing Luo, Chongliang Liu, Jia Fan, Rong Chen, Zhigang Chen, Yong Peng, Fuhua Jiang, Ying Front Neurol Neurology Objective: Homocysteine (Hcy) levels have been investigated in many diseases, such as neurodegenerative and autoimmune diseases. However, changes in Hcy levels in anti-N-Methyl-D-aspartate receptor (anti-NMDAR) encephalitis have not been investigated thus far. Methods: Case data were collected from 45 patients with anti-NMDAR encephalitis and 179 age- and sex-matched healthy controls (HCs). Clinical characteristics, Hcy levels, C reactive protein (CRP) levels, and cerebrospinal fluid (CSF) parameters were determined. Association of Hcy and clinical parameters were evaluated in these patients. Among these 45 patients, 15 had a follow-up evaluation at 3 months after treatment. Results: Hcy levels (p < 0.001) and CRP levels (p = 0.005) from the patients with anti-NMDAR encephalitis were significantly higher than those from HCs. Hcy levels from male patients were significantly lower than those from male HCs (p < 0.001). Comparing anti-NMDAR encephalitis patients after treatment with before treatment, the former has significantly higher Hcy levels (p = 0.004), CRP levels (p = 0.041) and mRS scores (p = 0.002). Furthermore, a significant negative correlation between the changes in Hcy levels and the changes in mRS scores (r = −0.534, p = 0.040) was observed. Conclusion: Elevated plasma homocysteine occurs in anti-NMDAR encephalitis, and seems associated with male sex. Frontiers Media S.A. 2019-05-03 /pmc/articles/PMC6509947/ /pubmed/31130913 http://dx.doi.org/10.3389/fneur.2019.00464 Text en Copyright © 2019 Liu, Liang, Liu, Luo, Liu, Fan, Chen, Chen, Peng and Jiang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Liu, Lizhi Liang, Jie Liu, Qing Luo, Chongliang Liu, Jia Fan, Rong Chen, Zhigang Chen, Yong Peng, Fuhua Jiang, Ying Elevated Plasma Homocysteine Levels in Anti-N-methyl-D-aspartate Receptor Encephalitis |
title | Elevated Plasma Homocysteine Levels in Anti-N-methyl-D-aspartate Receptor Encephalitis |
title_full | Elevated Plasma Homocysteine Levels in Anti-N-methyl-D-aspartate Receptor Encephalitis |
title_fullStr | Elevated Plasma Homocysteine Levels in Anti-N-methyl-D-aspartate Receptor Encephalitis |
title_full_unstemmed | Elevated Plasma Homocysteine Levels in Anti-N-methyl-D-aspartate Receptor Encephalitis |
title_short | Elevated Plasma Homocysteine Levels in Anti-N-methyl-D-aspartate Receptor Encephalitis |
title_sort | elevated plasma homocysteine levels in anti-n-methyl-d-aspartate receptor encephalitis |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509947/ https://www.ncbi.nlm.nih.gov/pubmed/31130913 http://dx.doi.org/10.3389/fneur.2019.00464 |
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