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X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation
Radiotherapy-related pain is a common adverse reaction with a high incidence among cancer patients undergoing radiotherapy and remarkably reduces the quality of life. However, the mechanisms of ionizing radiation-induced pain are largely unknown. In this study, mice were treated with 20 Gy X-ray to...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509987/ https://www.ncbi.nlm.nih.gov/pubmed/31012378 http://dx.doi.org/10.1177/1744806919849201 |
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author | Cun-Jin, Su Jian-Hao, Xu Xu, Liu Feng-Lun, Zhao Jie, Pan Ai-Ming, Shi Duan-Min, Hu Yun-Li, Yu Tong, Liu Yu-Song, Zhang |
author_facet | Cun-Jin, Su Jian-Hao, Xu Xu, Liu Feng-Lun, Zhao Jie, Pan Ai-Ming, Shi Duan-Min, Hu Yun-Li, Yu Tong, Liu Yu-Song, Zhang |
author_sort | Cun-Jin, Su |
collection | PubMed |
description | Radiotherapy-related pain is a common adverse reaction with a high incidence among cancer patients undergoing radiotherapy and remarkably reduces the quality of life. However, the mechanisms of ionizing radiation-induced pain are largely unknown. In this study, mice were treated with 20 Gy X-ray to establish ionizing radiation-induced pain model. X-ray evoked a prolonged mechanical, heat, and cold allodynia in mice. Transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 were significantly upregulated in lumbar dorsal root ganglion. The mechanical and heat allodynia could be transiently reverted by intrathecal injection of transient receptor potential vanilloid 1 antagonist capsazepine and transient receptor potential ankyrin 1 antagonist HC-030031. Additionally, the phosphorylated extracellular regulated protein kinases (ERK) and Jun NH2-terminal Kinase (JNK) in pain neural pathway were induced by X-ray treatment. Our findings indicated that activation of transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 is essential for the development of X-ray-induced allodynia. Furthermore, our findings suggest that targeting on transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 may be promising prevention strategies for X-ray-induced allodynia in clinical practice. |
format | Online Article Text |
id | pubmed-6509987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-65099872019-05-17 X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation Cun-Jin, Su Jian-Hao, Xu Xu, Liu Feng-Lun, Zhao Jie, Pan Ai-Ming, Shi Duan-Min, Hu Yun-Li, Yu Tong, Liu Yu-Song, Zhang Mol Pain Research Article Radiotherapy-related pain is a common adverse reaction with a high incidence among cancer patients undergoing radiotherapy and remarkably reduces the quality of life. However, the mechanisms of ionizing radiation-induced pain are largely unknown. In this study, mice were treated with 20 Gy X-ray to establish ionizing radiation-induced pain model. X-ray evoked a prolonged mechanical, heat, and cold allodynia in mice. Transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 were significantly upregulated in lumbar dorsal root ganglion. The mechanical and heat allodynia could be transiently reverted by intrathecal injection of transient receptor potential vanilloid 1 antagonist capsazepine and transient receptor potential ankyrin 1 antagonist HC-030031. Additionally, the phosphorylated extracellular regulated protein kinases (ERK) and Jun NH2-terminal Kinase (JNK) in pain neural pathway were induced by X-ray treatment. Our findings indicated that activation of transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 is essential for the development of X-ray-induced allodynia. Furthermore, our findings suggest that targeting on transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 may be promising prevention strategies for X-ray-induced allodynia in clinical practice. SAGE Publications 2019-05-09 /pmc/articles/PMC6509987/ /pubmed/31012378 http://dx.doi.org/10.1177/1744806919849201 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Research Article Cun-Jin, Su Jian-Hao, Xu Xu, Liu Feng-Lun, Zhao Jie, Pan Ai-Ming, Shi Duan-Min, Hu Yun-Li, Yu Tong, Liu Yu-Song, Zhang X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation |
title | X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation |
title_full | X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation |
title_fullStr | X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation |
title_full_unstemmed | X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation |
title_short | X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation |
title_sort | x-ray induces mechanical and heat allodynia in mouse via trpa1 and trpv1 activation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509987/ https://www.ncbi.nlm.nih.gov/pubmed/31012378 http://dx.doi.org/10.1177/1744806919849201 |
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