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Role of Exosomes in Crosstalk Between Cancer-Associated Fibroblasts and Cancer Cells

Cancer-associated fibroblasts (CAFs) are important cells of the tumor microenvironment that can communicate with tumor cells through various mechanisms. Recently, increasing studies have found that exosomes transmit biological information by carrying microRNAs, lncRNAs, proteins, metabolites, and ot...

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Detalles Bibliográficos
Autores principales: Yang, Xi, Li, Yida, Zou, Liqing, Zhu, Zhengfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510008/
https://www.ncbi.nlm.nih.gov/pubmed/31131261
http://dx.doi.org/10.3389/fonc.2019.00356
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author Yang, Xi
Li, Yida
Zou, Liqing
Zhu, Zhengfei
author_facet Yang, Xi
Li, Yida
Zou, Liqing
Zhu, Zhengfei
author_sort Yang, Xi
collection PubMed
description Cancer-associated fibroblasts (CAFs) are important cells of the tumor microenvironment that can communicate with tumor cells through various mechanisms. Recently, increasing studies have found that exosomes transmit biological information by carrying microRNAs, lncRNAs, proteins, metabolites, and other substances, and thus exert biological and therapeutic effects. CAF-secreted exosomes can also affect the tumor phenotype, while the exosomes released by tumor cells can activate CAFs. Here, we review the role of exosomes in the crosstalk between CAFs and tumor cells and elaborate its mechanism.
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spelling pubmed-65100082019-05-24 Role of Exosomes in Crosstalk Between Cancer-Associated Fibroblasts and Cancer Cells Yang, Xi Li, Yida Zou, Liqing Zhu, Zhengfei Front Oncol Oncology Cancer-associated fibroblasts (CAFs) are important cells of the tumor microenvironment that can communicate with tumor cells through various mechanisms. Recently, increasing studies have found that exosomes transmit biological information by carrying microRNAs, lncRNAs, proteins, metabolites, and other substances, and thus exert biological and therapeutic effects. CAF-secreted exosomes can also affect the tumor phenotype, while the exosomes released by tumor cells can activate CAFs. Here, we review the role of exosomes in the crosstalk between CAFs and tumor cells and elaborate its mechanism. Frontiers Media S.A. 2019-05-03 /pmc/articles/PMC6510008/ /pubmed/31131261 http://dx.doi.org/10.3389/fonc.2019.00356 Text en Copyright © 2019 Yang, Li, Zou and Zhu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yang, Xi
Li, Yida
Zou, Liqing
Zhu, Zhengfei
Role of Exosomes in Crosstalk Between Cancer-Associated Fibroblasts and Cancer Cells
title Role of Exosomes in Crosstalk Between Cancer-Associated Fibroblasts and Cancer Cells
title_full Role of Exosomes in Crosstalk Between Cancer-Associated Fibroblasts and Cancer Cells
title_fullStr Role of Exosomes in Crosstalk Between Cancer-Associated Fibroblasts and Cancer Cells
title_full_unstemmed Role of Exosomes in Crosstalk Between Cancer-Associated Fibroblasts and Cancer Cells
title_short Role of Exosomes in Crosstalk Between Cancer-Associated Fibroblasts and Cancer Cells
title_sort role of exosomes in crosstalk between cancer-associated fibroblasts and cancer cells
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510008/
https://www.ncbi.nlm.nih.gov/pubmed/31131261
http://dx.doi.org/10.3389/fonc.2019.00356
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