A hypercoagulable state leading to venous limb gangrene associated with occult lung adenocarcinoma

We report a case of lung adenocarcinoma‐associated hypercoagulability leading to venous limb gangrene, managed successfully with argatroban and then dabigatran. Use of idarucizumab permitted diagnostic investigations, leading to targeted antineoplastic therapy with crizotinib, surgical resection wit...

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Autores principales: Waite, Matthew M. A., Martinelli, Anthony W., Preston, Stephen D., Gudgin, Emma, Symington, Emily, Rintoul, Robert C., Peryt, Adam, Coughlin, Patrick, Hayes, Paul, Gilligan, David, Besser, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510014/
https://www.ncbi.nlm.nih.gov/pubmed/31110709
http://dx.doi.org/10.1002/ccr3.2106
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author Waite, Matthew M. A.
Martinelli, Anthony W.
Preston, Stephen D.
Gudgin, Emma
Symington, Emily
Rintoul, Robert C.
Peryt, Adam
Coughlin, Patrick
Hayes, Paul
Gilligan, David
Besser, Martin
author_facet Waite, Matthew M. A.
Martinelli, Anthony W.
Preston, Stephen D.
Gudgin, Emma
Symington, Emily
Rintoul, Robert C.
Peryt, Adam
Coughlin, Patrick
Hayes, Paul
Gilligan, David
Besser, Martin
author_sort Waite, Matthew M. A.
collection PubMed
description We report a case of lung adenocarcinoma‐associated hypercoagulability leading to venous limb gangrene, managed successfully with argatroban and then dabigatran. Use of idarucizumab permitted diagnostic investigations, leading to targeted antineoplastic therapy with crizotinib, surgical resection with curative intent, and continued survival over 2 years after the index event.
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spelling pubmed-65100142019-05-20 A hypercoagulable state leading to venous limb gangrene associated with occult lung adenocarcinoma Waite, Matthew M. A. Martinelli, Anthony W. Preston, Stephen D. Gudgin, Emma Symington, Emily Rintoul, Robert C. Peryt, Adam Coughlin, Patrick Hayes, Paul Gilligan, David Besser, Martin Clin Case Rep Case Reports We report a case of lung adenocarcinoma‐associated hypercoagulability leading to venous limb gangrene, managed successfully with argatroban and then dabigatran. Use of idarucizumab permitted diagnostic investigations, leading to targeted antineoplastic therapy with crizotinib, surgical resection with curative intent, and continued survival over 2 years after the index event. John Wiley and Sons Inc. 2019-03-25 /pmc/articles/PMC6510014/ /pubmed/31110709 http://dx.doi.org/10.1002/ccr3.2106 Text en © 2019 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Waite, Matthew M. A.
Martinelli, Anthony W.
Preston, Stephen D.
Gudgin, Emma
Symington, Emily
Rintoul, Robert C.
Peryt, Adam
Coughlin, Patrick
Hayes, Paul
Gilligan, David
Besser, Martin
A hypercoagulable state leading to venous limb gangrene associated with occult lung adenocarcinoma
title A hypercoagulable state leading to venous limb gangrene associated with occult lung adenocarcinoma
title_full A hypercoagulable state leading to venous limb gangrene associated with occult lung adenocarcinoma
title_fullStr A hypercoagulable state leading to venous limb gangrene associated with occult lung adenocarcinoma
title_full_unstemmed A hypercoagulable state leading to venous limb gangrene associated with occult lung adenocarcinoma
title_short A hypercoagulable state leading to venous limb gangrene associated with occult lung adenocarcinoma
title_sort hypercoagulable state leading to venous limb gangrene associated with occult lung adenocarcinoma
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510014/
https://www.ncbi.nlm.nih.gov/pubmed/31110709
http://dx.doi.org/10.1002/ccr3.2106
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