Cargando…

LmbU, a Cluster-Situated Regulator for Lincomycin, Consists of a DNA-Binding Domain, an Auto-Inhibitory Domain, and Forms Homodimer

Few studies were reported about the regulatory mechanism of lincomycin biosynthesis since it was found in 1962. Although we have proved that a cluster-situated regulator (CSR) LmbU (GenBank Accession No. ABX00623.1) positively modulates lincomycin biosynthesis in Streptomyces lincolnensis NRRL 2936,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hou, Bingbing, Zhu, Xiaoyu, Kang, Yajing, Wang, Ruida, Wu, Haizhen, Ye, Jiang, Zhang, Huizhan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510168/ https://www.ncbi.nlm.nih.gov/pubmed/31130942 http://dx.doi.org/10.3389/fmicb.2019.00989

Ejemplares similares

Comparative transcriptomic analysis reveals the significant pleiotropic regulatory effects of LmbU on lincomycin biosynthesis
por: Lin, Chun-Yan, et al.
Publicado: (2020)

AdpA(lin), a Pleiotropic Transcriptional Regulator, Is Involved in the Cascade Regulation of Lincomycin Biosynthesis in Streptomyces lincolnensis
por: Kang, Yajing, et al.
Publicado: (2019)

Complete genome sequence of high-yield strain S. lincolnensis B48 and identification of crucial mutations contributing to lincomycin overproduction
por: Wang, Ruida, et al.
Publicado: (2020)

Human MOSPD2: A bacterial Lmb mimicked auto-antigen is involved in immune infertility
por: Parida, Rajeshwari
Publicado: (2019)

Structural analysis of the PATZ1 BTB domain homodimer
por: Piepoli, Sofia, et al.
Publicado: (2020)

Molecular architecture of the ErbB2 extracellular domain homodimer
por: Hu, Shi, et al.
Publicado: (2015)

Structure and Function of the LmbE-like Superfamily
por: Viars, Shane, et al.
Publicado: (2014)

Enhanced Expression of lmb Gene Encoding Laminin-Binding Protein in Streptococcus agalactiae Strains Harboring IS1548 in scpB-lmb Intergenic Region
por: Al Safadi, Rim, et al.
Publicado: (2010)

Quantification of lincomycin resistance genes associated with lincomycin residues in waters and soils adjacent to representative swine farms in China
por: Li, Liang, et al.
Publicado: (2013)

Phosphorylation of a C-terminal auto-inhibitory domain increases SMARCAL1 activity
por: Carroll, Clinton, et al.
Publicado: (2014)

Rituximab in addition to LMB-based chemotherapy regimen in children and adolescents with primary mediastinal large B-cell lymphoma: results of the French LMB2001 prospective study
por: Dourthe, Marie Emilie, et al.
Publicado: (2022)

Balancing acts of SRI and an auto-inhibitory domain specify Set2 function at transcribed chromatin
por: Wang, Yi, et al.
Publicado: (2015)

The auto-inhibitory domain and ATP-independent microtubule-binding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germline
por: Williams, Lucy S., et al.
Publicado: (2014)

The C-Terminal Domain of the MutL Homolog from Neisseria gonorrhoeae Forms an Inverted Homodimer
por: Namadurai, Sivakumar, et al.
Publicado: (2010)

Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation
por: Zheng, Xunhai, et al.
Publicado: (2014)

Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association
por: Kukuk, Laura, et al.
Publicado: (2019)

Improving the consistency of domain annotation within the Conserved Domain Database
por: Derbyshire, Myra K., et al.
Publicado: (2015)

Completeness and Consistency in Structural Domain Classifications
por: Schaeffer, R. Dustin, et al.
Publicado: (2021)

Metal Binding Is Critical for the Folding and Function of Laminin Binding Protein, Lmb of Streptococcus agalactiae
por: Ragunathan, Preethi, et al.
Publicado: (2013)

Zn(2+) Uptake in Streptococcus pyogenes: Characterization of adcA and lmb Null Mutants
por: Tedde, Vittorio, et al.
Publicado: (2016)

Systemic immune changes accompany combination treatment with immunotoxin LMB‐100 and nab‐paclitaxel
por: Pegna, Guillaume Joe, et al.
Publicado: (2022)

Hypochlorous Acid-Activated UCNPs-LMB/VQIVYK Multifunctional Nanosystem for Alzheimer’s Disease Treatment
por: Qiao, Luying, et al.
Publicado: (2023)

A novel interface between the N-terminal and coiled-coil domain of STAT1 functions in an auto-inhibitory manner
por: Remling, Linus, et al.
Publicado: (2023)

Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG
por: Li, Xiaohua, et al.
Publicado: (2012)

Prophage protein RacR activates lysozyme LysN, causing the growth defect of E. coli JM83
por: Tang, Qiongwei, et al.
Publicado: (2019)

sRNA EsrE Is Transcriptionally Regulated by the Ferric Uptake Regulator Fur in Escherichia coli
por: Hou, Bingbing, et al.
Publicado: (2020)

Stability studies of lincomycin hydrochloride in aqueous solution and intravenous infusion fluids
por: Czarniak, Petra, et al.
Publicado: (2016)

Safety evaluation study of lincomycin and spectinomycin hydrochloride intramuscular injection in chickens
por: Khan, Ejaz Ali, et al.
Publicado: (2022)

Lincomycin HCl-Loaded Borneol-Based In Situ Gel for Periodontitis Treatment
por: Puyathorn, Napaphol, et al.
Publicado: (2023)

The Vesicle Priming Factor CAPS Functions as a Homodimer via C2 Domain Interactions to Promote Regulated Vesicle Exocytosis
por: Petrie, Matt, et al.
Publicado: (2016)

Soil Behaviour of the Veterinary Drugs Lincomycin, Monensin, and Roxarsone and Their Toxicity on Environmental Organisms
por: Li, Peiyi, et al.
Publicado: (2019)

Hemolytic Activity, Cytotoxicity, and Antimicrobial Effects of Silver Nanoparticles Conjugated with Lincomycin or Cefazolin
por: Korolev, Dmitriy, et al.
Publicado: (2022)

The adcA and lmb Genes Play an Important Role in Drug Resistance and Full Virulence of Streptococcus suis
por: Peng, Mingzheng, et al.
Publicado: (2023)

Domain Adaptation for Pedestrian Detection Based on Prediction Consistency
por: Li-ping, Yu, et al.
Publicado: (2014)

The Monitoring of Mycoplasma gallisepticum Minimum Inhibitory Concentrations during the Last Decade (2010–2020) Seems to Reveal a Comeback of Susceptibility to Macrolides, Tiamulin, and Lincomycin
por: Bottinelli, Marco, et al.
Publicado: (2022)

The Putative Auto-Inhibitory Domain of Durum Wheat Catalase (TdCAT1) Positively Regulates Bacteria Cells in Response to Different Stress Conditions
por: Ghorbel, Mouna, et al.
Publicado: (2022)

Cross-reactivities between human IgMs and the four serotypes of dengue virus as probed with artificial homodimers of domain-III from the envelope proteins
por: Zidane, Nora, et al.
Publicado: (2013)

Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell–cell adhesion
por: Shimizu, Hideaki, et al.
Publicado: (2017)

Formation of stable homodimer via the C-terminal α-helical domain of coronavirus nonstructural protein 9 is critical for its function in viral replication
por: Chen, Bo, et al.
Publicado: (2009)

Complete Genome Sequence of Vibrio campbellii LMB 29 Isolated from Red Drum with Four Native Megaplasmids
por: Liu, Jinxin, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_g3n1hq3445vsv2q3bh39r6idq8