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The ACCOuNT Consortium: A Model for the Discovery, Translation, and Implementation of Precision Medicine in African Americans
The majority of pharmacogenomic (PGx) studies have been conducted on European ancestry populations, thereby excluding minority populations and impeding the discovery and translation of African American–specific genetic variation into precision medicine. Without accounting for variants found in Afric...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510376/ https://www.ncbi.nlm.nih.gov/pubmed/30592548 http://dx.doi.org/10.1111/cts.12608 |
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author | Friedman, Paula N. Shaazuddin, Mohammed Gong, Li Grossman, Robert L. Harralson, Arthur F. Klein, Teri E. Lee, Norman H. Miller, Doriane C. Nutescu, Edith A. O'Brien, Travis J. O'Donnell, Peter H. O'Leary, Kevin J. Tuck, Matthew Meltzer, David O. Perera, Minoli A. |
author_facet | Friedman, Paula N. Shaazuddin, Mohammed Gong, Li Grossman, Robert L. Harralson, Arthur F. Klein, Teri E. Lee, Norman H. Miller, Doriane C. Nutescu, Edith A. O'Brien, Travis J. O'Donnell, Peter H. O'Leary, Kevin J. Tuck, Matthew Meltzer, David O. Perera, Minoli A. |
author_sort | Friedman, Paula N. |
collection | PubMed |
description | The majority of pharmacogenomic (PGx) studies have been conducted on European ancestry populations, thereby excluding minority populations and impeding the discovery and translation of African American–specific genetic variation into precision medicine. Without accounting for variants found in African Americans, clinical recommendations based solely on genetic biomarkers found in European populations could result in misclassification of drug response in African American patients. To address these challenges, we formed the Transdisciplinary Collaborative Center (TCC), African American Cardiovascular Pharmacogenetic Consortium (ACCOuNT), to discover novel genetic variants in African Americans related to clinically actionable cardiovascular phenotypes and to incorporate African American–specific sequence variations into clinical recommendations at the point of care. The TCC consists of two research projects focused on discovery and translation of genetic findings and four cores that support the projects. In addition, the largest repository of PGx information on African Americans is being established as well as lasting infrastructure that can be utilized to spur continued research in this understudied population. |
format | Online Article Text |
id | pubmed-6510376 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65103762019-05-20 The ACCOuNT Consortium: A Model for the Discovery, Translation, and Implementation of Precision Medicine in African Americans Friedman, Paula N. Shaazuddin, Mohammed Gong, Li Grossman, Robert L. Harralson, Arthur F. Klein, Teri E. Lee, Norman H. Miller, Doriane C. Nutescu, Edith A. O'Brien, Travis J. O'Donnell, Peter H. O'Leary, Kevin J. Tuck, Matthew Meltzer, David O. Perera, Minoli A. Clin Transl Sci Review The majority of pharmacogenomic (PGx) studies have been conducted on European ancestry populations, thereby excluding minority populations and impeding the discovery and translation of African American–specific genetic variation into precision medicine. Without accounting for variants found in African Americans, clinical recommendations based solely on genetic biomarkers found in European populations could result in misclassification of drug response in African American patients. To address these challenges, we formed the Transdisciplinary Collaborative Center (TCC), African American Cardiovascular Pharmacogenetic Consortium (ACCOuNT), to discover novel genetic variants in African Americans related to clinically actionable cardiovascular phenotypes and to incorporate African American–specific sequence variations into clinical recommendations at the point of care. The TCC consists of two research projects focused on discovery and translation of genetic findings and four cores that support the projects. In addition, the largest repository of PGx information on African Americans is being established as well as lasting infrastructure that can be utilized to spur continued research in this understudied population. John Wiley and Sons Inc. 2019-02-12 2019-05 /pmc/articles/PMC6510376/ /pubmed/30592548 http://dx.doi.org/10.1111/cts.12608 Text en © 2018 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Review Friedman, Paula N. Shaazuddin, Mohammed Gong, Li Grossman, Robert L. Harralson, Arthur F. Klein, Teri E. Lee, Norman H. Miller, Doriane C. Nutescu, Edith A. O'Brien, Travis J. O'Donnell, Peter H. O'Leary, Kevin J. Tuck, Matthew Meltzer, David O. Perera, Minoli A. The ACCOuNT Consortium: A Model for the Discovery, Translation, and Implementation of Precision Medicine in African Americans |
title | The ACCOuNT Consortium: A Model for the Discovery, Translation, and Implementation of Precision Medicine in African Americans |
title_full | The ACCOuNT Consortium: A Model for the Discovery, Translation, and Implementation of Precision Medicine in African Americans |
title_fullStr | The ACCOuNT Consortium: A Model for the Discovery, Translation, and Implementation of Precision Medicine in African Americans |
title_full_unstemmed | The ACCOuNT Consortium: A Model for the Discovery, Translation, and Implementation of Precision Medicine in African Americans |
title_short | The ACCOuNT Consortium: A Model for the Discovery, Translation, and Implementation of Precision Medicine in African Americans |
title_sort | account consortium: a model for the discovery, translation, and implementation of precision medicine in african americans |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510376/ https://www.ncbi.nlm.nih.gov/pubmed/30592548 http://dx.doi.org/10.1111/cts.12608 |
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