Predicting Efavirenz Concentrations in the Brain Tissue of HIV‐Infected Individuals and Exploring their Relationship to Neurocognitive Impairment

Sparse data exist on the penetration of antiretrovirals into brain tissue. In this work, we present a framework to use efavirenz (EFV) pharmacokinetic (PK) data in plasma, cerebrospinal fluid (CSF), and brain tissue of eight rhesus macaques to predict brain tissue concentrations in HIV‐infected indi...

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Detalles Bibliográficos
Autores principales: Srinivas, Nithya, Joseph, Sarah Beth, Robertson, Kevin, Kincer, Laura P., Menezes, Prema, Adamson, Lourdes, Schauer, Amanda P., Blake, Kimberly H., White, Nicole, Sykes, Craig, Luciw, Paul, Eron, Joseph J., Forrest, Alan, Price, Richard W., Spudich, Serena, Swanstrom, Ronald, Kashuba, Angela D.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510381/
https://www.ncbi.nlm.nih.gov/pubmed/30675981
http://dx.doi.org/10.1111/cts.12620

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