Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease

BACKGROUND: Fibrinogen is an essential hemostatic factor and cardiovascular disease risk factor. Early attempts at evaluating the causal effect of fibrinogen on coronary heart disease (CHD) and myocardial infraction (MI) using Mendelian randomization (MR) used single variant approaches, and did not...

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Detalles Bibliográficos
Autores principales: Ward-Caviness, Cavin K., de Vries, Paul S., Wiggins, Kerri L., Huffman, Jennifer E., Yanek, Lisa R., Bielak, Lawrence F., Giulianini, Franco, Guo, Xiuqing, Kleber, Marcus E., Kacprowski, Tim, Groß, Stefan, Petersman, Astrid, Davey Smith, George, Hartwig, Fernando P., Bowden, Jack, Hemani, Gibran, Müller-Nuraysid, Martina, Strauch, Konstantin, Koenig, Wolfgang, Waldenberger, Melanie, Meitinger, Thomas, Pankratz, Nathan, Boerwinkle, Eric, Tang, Weihong, Fu, Yi-Ping, Johnson, Andrew D., Song, Ci, de Maat, Moniek P. M., Uitterlinden, André G., Franco, Oscar H., Brody, Jennifer A., McKnight, Barbara, Chen, Yii-Der Ida, Psaty, Bruce M., Mathias, Rasika A., Becker, Diane M., Peyser, Patricia A., Smith, Jennifer A., Bielinski, Suzette J., Ridker, Paul M., Taylor, Kent D., Yao, Jie, Tracy, Russell, Delgado, Graciela, Trompet, Stella, Sattar, Naveed, Jukema, J. Wouter, Becker, Lewis C., Kardia, Sharon L. R., Rotter, Jerome I., März, Winfried, Dörr, Marcus, Chasman, Daniel I., Dehghan, Abbas, O’Donnell, Christopher J., Smith, Nicholas L., Peters, Annette, Morrison, Alanna C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510421/
https://www.ncbi.nlm.nih.gov/pubmed/31075152
http://dx.doi.org/10.1371/journal.pone.0216222

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