A potent liver-mediated mechanism for loss of muscle mass during androgen deprivation therapy

CONTEXT: Androgen deprivation therapy (ADT) in prostate cancer results in muscular atrophy, due to loss of the anabolic actions of testosterone. Recently, we discovered that testosterone acts on the hepatic urea cycle to reduce amino acid nitrogen elimination. We now hypothesize that ADT enhances pr...

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Detalles Bibliográficos
Autores principales: Lam, Teresa, McLean, Mark, Hayden, Amy, Poljak, Anne, Cheema, Birinder, Gurney, Howard, Stone, Glenn, Bahl, Neha, Reddy, Navneeta, Shahidipour, Haleh, Birzniece, Vita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510709/
https://www.ncbi.nlm.nih.gov/pubmed/30991356
http://dx.doi.org/10.1530/EC-19-0179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510709/
https://www.ncbi.nlm.nih.gov/pubmed/30991356
http://dx.doi.org/10.1530/EC-19-0179

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