A functional CRISPR/Cas9 screen identifies kinases that modulate FGFR inhibitor response in gastric cancer

Some gastric cancers have FGFR2 amplifications, making them sensitive to FGFR inhibitors. However, cancer cells inevitably develop resistance despite initial response. The underlying resistance mechanism to FGFR inhibition is unclear. In this study, we applied a kinome-wide CRISPR/Cas9 screen to sys...

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Detalles Bibliográficos
Autores principales: Chen, Jiamin, Bell, John, Lau, Billy T., Whittaker, Tyler, Stapleton, Darren, Ji, Hanlee P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510732/
https://www.ncbi.nlm.nih.gov/pubmed/31076567
http://dx.doi.org/10.1038/s41389-019-0145-z

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