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Α Quantum Pattern Recognition Method for Improving Pairwise Sequence Alignment

Quantum pattern recognition techniques have recently raised attention as potential candidates in analyzing vast amount of data. The necessity to obtain faster ways to process data is imperative where data generation is rapid. The ever-growing size of sequence databases caused by the development of h...

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Detalles Bibliográficos
Autores principales: Prousalis, Konstantinos, Konofaos, Nikos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510764/
https://www.ncbi.nlm.nih.gov/pubmed/31076611
http://dx.doi.org/10.1038/s41598-019-43697-3
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author Prousalis, Konstantinos
Konofaos, Nikos
author_facet Prousalis, Konstantinos
Konofaos, Nikos
author_sort Prousalis, Konstantinos
collection PubMed
description Quantum pattern recognition techniques have recently raised attention as potential candidates in analyzing vast amount of data. The necessity to obtain faster ways to process data is imperative where data generation is rapid. The ever-growing size of sequence databases caused by the development of high throughput sequencing is unprecedented. Current alignment methods have blossomed overnight but there is still the need for more efficient methods that preserve accuracy in high levels. In this work, a complex method is proposed to treat the alignment problem better than its classical counterparts by means of quantum computation. The basic principal of the standard dot-plot method is combined with a quantum algorithm, giving insight into the effect of quantum pattern recognition on pairwise alignment. The central feature of quantum algorithmic -quantum parallelism- and the diffraction patterns of x-rays are synthesized to provide a clever array indexing structure on the growing sequence databases. A completely different approach is considered in contrast to contemporary conventional aligners and a variety of competitive classical counterparts are classified and organized in order to compare with the quantum setting. The proposed method seems to exhibit high alignment quality and prevail among the others in terms of time and space complexity.
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spelling pubmed-65107642019-05-23 Α Quantum Pattern Recognition Method for Improving Pairwise Sequence Alignment Prousalis, Konstantinos Konofaos, Nikos Sci Rep Article Quantum pattern recognition techniques have recently raised attention as potential candidates in analyzing vast amount of data. The necessity to obtain faster ways to process data is imperative where data generation is rapid. The ever-growing size of sequence databases caused by the development of high throughput sequencing is unprecedented. Current alignment methods have blossomed overnight but there is still the need for more efficient methods that preserve accuracy in high levels. In this work, a complex method is proposed to treat the alignment problem better than its classical counterparts by means of quantum computation. The basic principal of the standard dot-plot method is combined with a quantum algorithm, giving insight into the effect of quantum pattern recognition on pairwise alignment. The central feature of quantum algorithmic -quantum parallelism- and the diffraction patterns of x-rays are synthesized to provide a clever array indexing structure on the growing sequence databases. A completely different approach is considered in contrast to contemporary conventional aligners and a variety of competitive classical counterparts are classified and organized in order to compare with the quantum setting. The proposed method seems to exhibit high alignment quality and prevail among the others in terms of time and space complexity. Nature Publishing Group UK 2019-05-10 /pmc/articles/PMC6510764/ /pubmed/31076611 http://dx.doi.org/10.1038/s41598-019-43697-3 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Prousalis, Konstantinos
Konofaos, Nikos
Α Quantum Pattern Recognition Method for Improving Pairwise Sequence Alignment
title Α Quantum Pattern Recognition Method for Improving Pairwise Sequence Alignment
title_full Α Quantum Pattern Recognition Method for Improving Pairwise Sequence Alignment
title_fullStr Α Quantum Pattern Recognition Method for Improving Pairwise Sequence Alignment
title_full_unstemmed Α Quantum Pattern Recognition Method for Improving Pairwise Sequence Alignment
title_short Α Quantum Pattern Recognition Method for Improving Pairwise Sequence Alignment
title_sort α quantum pattern recognition method for improving pairwise sequence alignment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510764/
https://www.ncbi.nlm.nih.gov/pubmed/31076611
http://dx.doi.org/10.1038/s41598-019-43697-3
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