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A phospholipase D2 inhibitor, CAY10594, ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis

We examined the role of phospholipase D2 (PLD2) on acetaminophen (APAP)-induced acute liver injury using a PLD2 inhibitor (CAY10594). 500 mg/kg of APAP challenge caused acute liver damage. CAY10594 administration markedly blocked the acute liver injury in a dose-dependent manner, showing almost comp...

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Detalles Bibliográficos
Autores principales:	Lee, Sung Kyun, Bae, Geon Ho, Kim, Ye Seon, Kim, Hyung Sik, Lee, Mingyu, Ghim, Jaewang, Zabel, Brian A., Ryu, Sung Ho, Bae, Yoe-Sik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510900/ https://www.ncbi.nlm.nih.gov/pubmed/31076618 http://dx.doi.org/10.1038/s41598-019-43673-x

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