Data on the negative regulation of invadopodia activity by MLCK

Actomyosin contractility can promote extracellular matrix (ECM) degradation by invadopodia in cancer cells. However, we previously found that inhibiting myosin light chain kinase (MLCK) with siRNA did not change force generation by the head and neck squamous cell carcinoma (HNSCC) cell line SCC-61....

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Detalles Bibliográficos
Autores principales: Jerrell, Rachel J., Parekh, Aron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Biochemistry, Genetics and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510963/
https://www.ncbi.nlm.nih.gov/pubmed/31111082
http://dx.doi.org/10.1016/j.dib.2019.103939
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author Jerrell, Rachel J.
Parekh, Aron
author_facet Jerrell, Rachel J.
Parekh, Aron
author_sort Jerrell, Rachel J.
collection PubMed
description Actomyosin contractility can promote extracellular matrix (ECM) degradation by invadopodia in cancer cells. However, we previously found that inhibiting myosin light chain kinase (MLCK) with siRNA did not change force generation by the head and neck squamous cell carcinoma (HNSCC) cell line SCC-61. We provide data here that this targeted method of MLCK knockdown (KD) resulted in a significant increase in the amount of ECM degradation, number of actively degrading invadopodia, and the number of total invadopodia formed. These data are related to the research article entitled “Matrix rigidity differentially regulates invadopodia activity through ROCK1 and ROCK2” Jerrell and Parekh, 2016.
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spelling pubmed-65109632019-05-20 Data on the negative regulation of invadopodia activity by MLCK Jerrell, Rachel J. Parekh, Aron Data Brief Biochemistry, Genetics and Molecular Biology Actomyosin contractility can promote extracellular matrix (ECM) degradation by invadopodia in cancer cells. However, we previously found that inhibiting myosin light chain kinase (MLCK) with siRNA did not change force generation by the head and neck squamous cell carcinoma (HNSCC) cell line SCC-61. We provide data here that this targeted method of MLCK knockdown (KD) resulted in a significant increase in the amount of ECM degradation, number of actively degrading invadopodia, and the number of total invadopodia formed. These data are related to the research article entitled “Matrix rigidity differentially regulates invadopodia activity through ROCK1 and ROCK2” Jerrell and Parekh, 2016. Elsevier 2019-04-24 /pmc/articles/PMC6510963/ /pubmed/31111082 http://dx.doi.org/10.1016/j.dib.2019.103939 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Biochemistry, Genetics and Molecular Biology
Jerrell, Rachel J.
Parekh, Aron
Data on the negative regulation of invadopodia activity by MLCK
title Data on the negative regulation of invadopodia activity by MLCK
title_full Data on the negative regulation of invadopodia activity by MLCK
title_fullStr Data on the negative regulation of invadopodia activity by MLCK
title_full_unstemmed Data on the negative regulation of invadopodia activity by MLCK
title_short Data on the negative regulation of invadopodia activity by MLCK
title_sort data on the negative regulation of invadopodia activity by mlck
topic Biochemistry, Genetics and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510963/
https://www.ncbi.nlm.nih.gov/pubmed/31111082
http://dx.doi.org/10.1016/j.dib.2019.103939
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