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Cognitive and physical activity and dementia: A 44-year longitudinal population study of women

OBJECTIVE: To investigate whether cognitive and physical activities in midlife are associated with reduced risk of dementia and dementia subtypes in women followed for 44 years. METHODS: A population-based sample of 800 women aged 38–54 years (mean age 47 years) was followed from 1968 to 2012. Cogni...

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Autores principales: Najar, Jenna, Östling, Svante, Gudmundsson, Pia, Sundh, Valter, Johansson, Lena, Kern, Silke, Guo, Xinxin, Hällström, Tore, Skoog, Ingmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511097/
https://www.ncbi.nlm.nih.gov/pubmed/30787164
http://dx.doi.org/10.1212/WNL.0000000000007021
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author Najar, Jenna
Östling, Svante
Gudmundsson, Pia
Sundh, Valter
Johansson, Lena
Kern, Silke
Guo, Xinxin
Hällström, Tore
Skoog, Ingmar
author_facet Najar, Jenna
Östling, Svante
Gudmundsson, Pia
Sundh, Valter
Johansson, Lena
Kern, Silke
Guo, Xinxin
Hällström, Tore
Skoog, Ingmar
author_sort Najar, Jenna
collection PubMed
description OBJECTIVE: To investigate whether cognitive and physical activities in midlife are associated with reduced risk of dementia and dementia subtypes in women followed for 44 years. METHODS: A population-based sample of 800 women aged 38–54 years (mean age 47 years) was followed from 1968 to 2012. Cognitive (artistic, intellectual, manual, religious, and club) and physical activity were assessed at baseline. During follow-up, dementia (n = 194), Alzheimer disease (n = 102), vascular dementia (n = 27), mixed dementia (n = 41), and dementia with cerebrovascular disease (n = 81) were diagnosed according to established criteria based on information from neuropsychiatric examinations, informant interviews, hospital records, and registry data. Cox regression models were used with adjustment for age, education, socioeconomic status, hypertension, body mass index, cigarette smoking, diabetes mellitus, angina pectoris, stress, and major depression. RESULTS: We found that cognitive activity in midlife was associated with a reduced risk of total dementia (hazard ratio [HR] 0.66; 95% confidence interval [CI] 0.49–0.89) and Alzheimer disease (HR 0.54; 95% CI 0.36–0.82) during follow-up. Physical activity in midlife was associated with a reduced risk of mixed dementia (HR 0.43; 95% CI 0.22–0.86) and dementia with cerebrovascular disease (HR 0.47; 95% CI 0.28–0.78). The results were similar after excluding those who developed dementia before 1990 (n = 21), except that physical activity was then also associated with reduced risk of total dementia (HR 0.67; 95% CI 0.46–0.99). CONCLUSION: Our findings suggests that midlife cognitive and physical activities are independently associated with reduced risk of dementia and dementia subtypes. The results indicate that these midlife activities may have a role in preserving cognitive health in old age.
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spelling pubmed-65110972019-05-23 Cognitive and physical activity and dementia: A 44-year longitudinal population study of women Najar, Jenna Östling, Svante Gudmundsson, Pia Sundh, Valter Johansson, Lena Kern, Silke Guo, Xinxin Hällström, Tore Skoog, Ingmar Neurology Article OBJECTIVE: To investigate whether cognitive and physical activities in midlife are associated with reduced risk of dementia and dementia subtypes in women followed for 44 years. METHODS: A population-based sample of 800 women aged 38–54 years (mean age 47 years) was followed from 1968 to 2012. Cognitive (artistic, intellectual, manual, religious, and club) and physical activity were assessed at baseline. During follow-up, dementia (n = 194), Alzheimer disease (n = 102), vascular dementia (n = 27), mixed dementia (n = 41), and dementia with cerebrovascular disease (n = 81) were diagnosed according to established criteria based on information from neuropsychiatric examinations, informant interviews, hospital records, and registry data. Cox regression models were used with adjustment for age, education, socioeconomic status, hypertension, body mass index, cigarette smoking, diabetes mellitus, angina pectoris, stress, and major depression. RESULTS: We found that cognitive activity in midlife was associated with a reduced risk of total dementia (hazard ratio [HR] 0.66; 95% confidence interval [CI] 0.49–0.89) and Alzheimer disease (HR 0.54; 95% CI 0.36–0.82) during follow-up. Physical activity in midlife was associated with a reduced risk of mixed dementia (HR 0.43; 95% CI 0.22–0.86) and dementia with cerebrovascular disease (HR 0.47; 95% CI 0.28–0.78). The results were similar after excluding those who developed dementia before 1990 (n = 21), except that physical activity was then also associated with reduced risk of total dementia (HR 0.67; 95% CI 0.46–0.99). CONCLUSION: Our findings suggests that midlife cognitive and physical activities are independently associated with reduced risk of dementia and dementia subtypes. The results indicate that these midlife activities may have a role in preserving cognitive health in old age. Lippincott Williams & Wilkins 2019-03-19 /pmc/articles/PMC6511097/ /pubmed/30787164 http://dx.doi.org/10.1212/WNL.0000000000007021 Text en Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Najar, Jenna
Östling, Svante
Gudmundsson, Pia
Sundh, Valter
Johansson, Lena
Kern, Silke
Guo, Xinxin
Hällström, Tore
Skoog, Ingmar
Cognitive and physical activity and dementia: A 44-year longitudinal population study of women
title Cognitive and physical activity and dementia: A 44-year longitudinal population study of women
title_full Cognitive and physical activity and dementia: A 44-year longitudinal population study of women
title_fullStr Cognitive and physical activity and dementia: A 44-year longitudinal population study of women
title_full_unstemmed Cognitive and physical activity and dementia: A 44-year longitudinal population study of women
title_short Cognitive and physical activity and dementia: A 44-year longitudinal population study of women
title_sort cognitive and physical activity and dementia: a 44-year longitudinal population study of women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511097/
https://www.ncbi.nlm.nih.gov/pubmed/30787164
http://dx.doi.org/10.1212/WNL.0000000000007021
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