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Tissue-specific impact of stem-loops and quadruplexes on cancer breakpoints formation
BACKGROUND: Chromosomal rearrangements are the typical phenomena in cancer genomes causing gene disruptions and fusions, corruption of regulatory elements, damage to chromosome integrity. Among the factors contributing to genomic instability are non-B DNA structures with stem-loops and quadruplexes...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511154/ https://www.ncbi.nlm.nih.gov/pubmed/31077166 http://dx.doi.org/10.1186/s12885-019-5653-x |