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Letrozole supplementation during controlled ovarian stimulation in expected high responders: a pilot randomized controlled study
BACKGROUND: Almost all of the previous studies related with co-administration of letrozole in IVF cycles were performed in poor responders and letrozole may reduce the total gonadotropin dose required for ovarian stimulation, and the pregnancy rate did not decrease in poor responders. This study aim...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511177/ https://www.ncbi.nlm.nih.gov/pubmed/31077214 http://dx.doi.org/10.1186/s12958-019-0483-x |
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author | Yang, Xiaoyi Lin, Ge Lu, Guangxiu Gong, Fei |
author_facet | Yang, Xiaoyi Lin, Ge Lu, Guangxiu Gong, Fei |
author_sort | Yang, Xiaoyi |
collection | PubMed |
description | BACKGROUND: Almost all of the previous studies related with co-administration of letrozole in IVF cycles were performed in poor responders and letrozole may reduce the total gonadotropin dose required for ovarian stimulation, and the pregnancy rate did not decrease in poor responders. This study aimed to assess whether high responders co-treatment with letrozole reduced supraphysiological late follicular phase estradiol levels and the incidence of premature progesterone elevated at the end of the follicular phase, thereby impacting positively on endometrial receptivity. METHODS: A randomized parallel controlled study in a university-affiliated center include 130 high responders between October 2015 and August 2016. The patients were randomized on the first stimulation day of the IVF cycle and from stimulation day 5 receive letrozole (group A) or without letrozole treatment (group B). RESULTS: Although estradiol levels were significantly lower in the letrozole group (group A) (P < 0.001), progesterone elevation (> 1.5 ng/mL was considered as a rise) on the day of hCG triggering (15.4, 7.7%) was not statistically significant (P = 0.170). RecFSH, the recovery rate of eggs, the high-quality embryo rate, and the thickness of endometrium (P = 0.776) were similar between the letrozole group(group A) and control groups (group B). Clinical pregnancy rates were 53.1% (26/49) and 72.9% (35/48) in the letrozole and control groups, respectively, with a statistical significance (P = 0.043).Live birth rates were 42.9% (21/49) and 62.5% (30/48),showed a marginally significant difference (P = 0.053). The miscarriage rate did not significantly differ between the two groups. CONCLUSIONS: In this pilot study, letrozole supplementation could not reduce the incidence of premature progesterone rise during the late follicular phase in stimulated in vitro fertilization cycles in expected high responders, producing a harmful effect on the pregnancy outcome. TRIAL REGISTRATION: China Clinical Trial Registration Center: ChiCTR-IPR-15006211 URL of the trial registry record: http://www.chictr.org.cn/showproj.aspx?proj=10731. Trial registration date: 8 April, 2015. Date of first patient’s enrolment: 5 October, 2015. |
format | Online Article Text |
id | pubmed-6511177 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-65111772019-05-20 Letrozole supplementation during controlled ovarian stimulation in expected high responders: a pilot randomized controlled study Yang, Xiaoyi Lin, Ge Lu, Guangxiu Gong, Fei Reprod Biol Endocrinol Research BACKGROUND: Almost all of the previous studies related with co-administration of letrozole in IVF cycles were performed in poor responders and letrozole may reduce the total gonadotropin dose required for ovarian stimulation, and the pregnancy rate did not decrease in poor responders. This study aimed to assess whether high responders co-treatment with letrozole reduced supraphysiological late follicular phase estradiol levels and the incidence of premature progesterone elevated at the end of the follicular phase, thereby impacting positively on endometrial receptivity. METHODS: A randomized parallel controlled study in a university-affiliated center include 130 high responders between October 2015 and August 2016. The patients were randomized on the first stimulation day of the IVF cycle and from stimulation day 5 receive letrozole (group A) or without letrozole treatment (group B). RESULTS: Although estradiol levels were significantly lower in the letrozole group (group A) (P < 0.001), progesterone elevation (> 1.5 ng/mL was considered as a rise) on the day of hCG triggering (15.4, 7.7%) was not statistically significant (P = 0.170). RecFSH, the recovery rate of eggs, the high-quality embryo rate, and the thickness of endometrium (P = 0.776) were similar between the letrozole group(group A) and control groups (group B). Clinical pregnancy rates were 53.1% (26/49) and 72.9% (35/48) in the letrozole and control groups, respectively, with a statistical significance (P = 0.043).Live birth rates were 42.9% (21/49) and 62.5% (30/48),showed a marginally significant difference (P = 0.053). The miscarriage rate did not significantly differ between the two groups. CONCLUSIONS: In this pilot study, letrozole supplementation could not reduce the incidence of premature progesterone rise during the late follicular phase in stimulated in vitro fertilization cycles in expected high responders, producing a harmful effect on the pregnancy outcome. TRIAL REGISTRATION: China Clinical Trial Registration Center: ChiCTR-IPR-15006211 URL of the trial registry record: http://www.chictr.org.cn/showproj.aspx?proj=10731. Trial registration date: 8 April, 2015. Date of first patient’s enrolment: 5 October, 2015. BioMed Central 2019-05-10 /pmc/articles/PMC6511177/ /pubmed/31077214 http://dx.doi.org/10.1186/s12958-019-0483-x Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Yang, Xiaoyi Lin, Ge Lu, Guangxiu Gong, Fei Letrozole supplementation during controlled ovarian stimulation in expected high responders: a pilot randomized controlled study |
title | Letrozole supplementation during controlled ovarian stimulation in expected high responders: a pilot randomized controlled study |
title_full | Letrozole supplementation during controlled ovarian stimulation in expected high responders: a pilot randomized controlled study |
title_fullStr | Letrozole supplementation during controlled ovarian stimulation in expected high responders: a pilot randomized controlled study |
title_full_unstemmed | Letrozole supplementation during controlled ovarian stimulation in expected high responders: a pilot randomized controlled study |
title_short | Letrozole supplementation during controlled ovarian stimulation in expected high responders: a pilot randomized controlled study |
title_sort | letrozole supplementation during controlled ovarian stimulation in expected high responders: a pilot randomized controlled study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511177/ https://www.ncbi.nlm.nih.gov/pubmed/31077214 http://dx.doi.org/10.1186/s12958-019-0483-x |
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