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Circular RNAs as potential biomarkers and therapeutics for cardiovascular disease
Circular RNAs (circRNAs) are genetic regulators that were earlier considered as “junk”. In contrast to linear RNAs, they have covalently linked ends with no polyadenylated tails. CircRNAs can act as RNA-binding proteins, sequestering agents, transcriptional regulators, as well as microRNA sponges. I...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511224/ https://www.ncbi.nlm.nih.gov/pubmed/31119072 http://dx.doi.org/10.7717/peerj.6831 |
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author | Wang, Weitie Wang, Yong Piao, Hulin Li, Bo Huang, Maoxun Zhu, Zhicheng Li, Dan Wang, Tiance Xu, Rihao Liu, Kexiang |
author_facet | Wang, Weitie Wang, Yong Piao, Hulin Li, Bo Huang, Maoxun Zhu, Zhicheng Li, Dan Wang, Tiance Xu, Rihao Liu, Kexiang |
author_sort | Wang, Weitie |
collection | PubMed |
description | Circular RNAs (circRNAs) are genetic regulators that were earlier considered as “junk”. In contrast to linear RNAs, they have covalently linked ends with no polyadenylated tails. CircRNAs can act as RNA-binding proteins, sequestering agents, transcriptional regulators, as well as microRNA sponges. In addition, it is reported that some selected circRNAs are transformed into functional proteins. These RNA molecules always circularize through covalent bonds, and their presence has been demonstrated across species. They are usually abundant and stable as well as evolutionarily conserved in tissues (liver, lung, stomach), saliva, exosomes, and blood. Therefore, they have been proposed as the “next big thing” in molecular biomarkers for several diseases, particularly in cancer. Recently, circRNAs have been investigated in cardiovascular diseases (CVD) and reported to play important roles in heart failure, coronary artery disease, and myocardial infarction. Here, we review the recent literature and discuss the impact and the diagnostic and prognostic values of circRNAs in CVD. |
format | Online Article Text |
id | pubmed-6511224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65112242019-05-22 Circular RNAs as potential biomarkers and therapeutics for cardiovascular disease Wang, Weitie Wang, Yong Piao, Hulin Li, Bo Huang, Maoxun Zhu, Zhicheng Li, Dan Wang, Tiance Xu, Rihao Liu, Kexiang PeerJ Bioinformatics Circular RNAs (circRNAs) are genetic regulators that were earlier considered as “junk”. In contrast to linear RNAs, they have covalently linked ends with no polyadenylated tails. CircRNAs can act as RNA-binding proteins, sequestering agents, transcriptional regulators, as well as microRNA sponges. In addition, it is reported that some selected circRNAs are transformed into functional proteins. These RNA molecules always circularize through covalent bonds, and their presence has been demonstrated across species. They are usually abundant and stable as well as evolutionarily conserved in tissues (liver, lung, stomach), saliva, exosomes, and blood. Therefore, they have been proposed as the “next big thing” in molecular biomarkers for several diseases, particularly in cancer. Recently, circRNAs have been investigated in cardiovascular diseases (CVD) and reported to play important roles in heart failure, coronary artery disease, and myocardial infarction. Here, we review the recent literature and discuss the impact and the diagnostic and prognostic values of circRNAs in CVD. PeerJ Inc. 2019-05-08 /pmc/articles/PMC6511224/ /pubmed/31119072 http://dx.doi.org/10.7717/peerj.6831 Text en © 2019 Wang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Bioinformatics Wang, Weitie Wang, Yong Piao, Hulin Li, Bo Huang, Maoxun Zhu, Zhicheng Li, Dan Wang, Tiance Xu, Rihao Liu, Kexiang Circular RNAs as potential biomarkers and therapeutics for cardiovascular disease |
title | Circular RNAs as potential biomarkers and therapeutics for cardiovascular disease |
title_full | Circular RNAs as potential biomarkers and therapeutics for cardiovascular disease |
title_fullStr | Circular RNAs as potential biomarkers and therapeutics for cardiovascular disease |
title_full_unstemmed | Circular RNAs as potential biomarkers and therapeutics for cardiovascular disease |
title_short | Circular RNAs as potential biomarkers and therapeutics for cardiovascular disease |
title_sort | circular rnas as potential biomarkers and therapeutics for cardiovascular disease |
topic | Bioinformatics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511224/ https://www.ncbi.nlm.nih.gov/pubmed/31119072 http://dx.doi.org/10.7717/peerj.6831 |
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