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Impact of Cold Ischemia Time on Outcomes of Deceased Donor Kidney Transplantation: An Analysis of a National Registry

BACKGROUND. Cold ischemia time (CIT) is known to impact kidney graft survival rates. We compare the impact of CIT on graft failure and mortality in circulatory death versus brain death donor kidneys and how it relates to donor age. METHODS. We used the prospective Dutch Organ Transplantation Registr...

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Autores principales: Peters-Sengers, Hessel, Houtzager, Julia H.E., Idu, Mirza M., Heemskerk, Martin B.A., van Heurn, Ernst L.W., Homan van der Heide, Jaap J., Kers, Jesper, Berger, Stefan P., van Gulik, Thomas M., Bemelman, Frederike J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511440/
https://www.ncbi.nlm.nih.gov/pubmed/31165083
http://dx.doi.org/10.1097/TXD.0000000000000888
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author Peters-Sengers, Hessel
Houtzager, Julia H.E.
Idu, Mirza M.
Heemskerk, Martin B.A.
van Heurn, Ernst L.W.
Homan van der Heide, Jaap J.
Kers, Jesper
Berger, Stefan P.
van Gulik, Thomas M.
Bemelman, Frederike J.
author_facet Peters-Sengers, Hessel
Houtzager, Julia H.E.
Idu, Mirza M.
Heemskerk, Martin B.A.
van Heurn, Ernst L.W.
Homan van der Heide, Jaap J.
Kers, Jesper
Berger, Stefan P.
van Gulik, Thomas M.
Bemelman, Frederike J.
author_sort Peters-Sengers, Hessel
collection PubMed
description BACKGROUND. Cold ischemia time (CIT) is known to impact kidney graft survival rates. We compare the impact of CIT on graft failure and mortality in circulatory death versus brain death donor kidneys and how it relates to donor age. METHODS. We used the prospective Dutch Organ Transplantation Registry to include 2153 adult recipients of brain death (n = 1266) and circulatory death (n = 887) donor kidneys after static cold storage from transplants performed between 2005 and 2012. CIT was modeled nonlinearly with splines. Associations and interactions between CIT, donor type, donor age, 5-year (death-censored) graft survival, and mortality were evaluated. RESULTS. The median CIT was 16.2 hours (interquartile range 12.8–20), ranging from 3.4 to 44.7 hours for brain death and 4.7 to 46.6 hours for circulatory death donor kidneys. At >12 hours of CIT, we observed an increased risk of graft failure in kidneys donated after circulatory death versus after brain death. This risk rose significantly at >22 hours of CIT (hazard ratio 1.45; 95% confidence interval, 1.01-2.49; P = 0.043). Kidneys that came from 60-year-old circulatory death donors demonstrated elevated hazard risk at 19 hours of CIT, a shorter timeline than that for kidneys that came from brain death donors of the same age (hazard ratio 1.33; 95% confidence interval, 1.00-1.78; P = 0.045). The additional harmful effects of increased CIT in kidneys from circulatory-death donors were also found for death-censored graft failure but did not affect mortality rates in any significant way. CONCLUSIONS. The findings support the hypothesis that prolonged cold ischemia is more harmful for circulatory death donor kidneys that have already been subjected to a permissible period of warm ischemia. Efforts should be made to reduce CIT, especially for older circulatory death donor kidneys.
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spelling pubmed-65114402019-06-04 Impact of Cold Ischemia Time on Outcomes of Deceased Donor Kidney Transplantation: An Analysis of a National Registry Peters-Sengers, Hessel Houtzager, Julia H.E. Idu, Mirza M. Heemskerk, Martin B.A. van Heurn, Ernst L.W. Homan van der Heide, Jaap J. Kers, Jesper Berger, Stefan P. van Gulik, Thomas M. Bemelman, Frederike J. Transplant Direct Kidney Transplantation BACKGROUND. Cold ischemia time (CIT) is known to impact kidney graft survival rates. We compare the impact of CIT on graft failure and mortality in circulatory death versus brain death donor kidneys and how it relates to donor age. METHODS. We used the prospective Dutch Organ Transplantation Registry to include 2153 adult recipients of brain death (n = 1266) and circulatory death (n = 887) donor kidneys after static cold storage from transplants performed between 2005 and 2012. CIT was modeled nonlinearly with splines. Associations and interactions between CIT, donor type, donor age, 5-year (death-censored) graft survival, and mortality were evaluated. RESULTS. The median CIT was 16.2 hours (interquartile range 12.8–20), ranging from 3.4 to 44.7 hours for brain death and 4.7 to 46.6 hours for circulatory death donor kidneys. At >12 hours of CIT, we observed an increased risk of graft failure in kidneys donated after circulatory death versus after brain death. This risk rose significantly at >22 hours of CIT (hazard ratio 1.45; 95% confidence interval, 1.01-2.49; P = 0.043). Kidneys that came from 60-year-old circulatory death donors demonstrated elevated hazard risk at 19 hours of CIT, a shorter timeline than that for kidneys that came from brain death donors of the same age (hazard ratio 1.33; 95% confidence interval, 1.00-1.78; P = 0.045). The additional harmful effects of increased CIT in kidneys from circulatory-death donors were also found for death-censored graft failure but did not affect mortality rates in any significant way. CONCLUSIONS. The findings support the hypothesis that prolonged cold ischemia is more harmful for circulatory death donor kidneys that have already been subjected to a permissible period of warm ischemia. Efforts should be made to reduce CIT, especially for older circulatory death donor kidneys. Wolters Kluwer Health 2019-04-25 /pmc/articles/PMC6511440/ /pubmed/31165083 http://dx.doi.org/10.1097/TXD.0000000000000888 Text en Copyright © 2019 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Kidney Transplantation
Peters-Sengers, Hessel
Houtzager, Julia H.E.
Idu, Mirza M.
Heemskerk, Martin B.A.
van Heurn, Ernst L.W.
Homan van der Heide, Jaap J.
Kers, Jesper
Berger, Stefan P.
van Gulik, Thomas M.
Bemelman, Frederike J.
Impact of Cold Ischemia Time on Outcomes of Deceased Donor Kidney Transplantation: An Analysis of a National Registry
title Impact of Cold Ischemia Time on Outcomes of Deceased Donor Kidney Transplantation: An Analysis of a National Registry
title_full Impact of Cold Ischemia Time on Outcomes of Deceased Donor Kidney Transplantation: An Analysis of a National Registry
title_fullStr Impact of Cold Ischemia Time on Outcomes of Deceased Donor Kidney Transplantation: An Analysis of a National Registry
title_full_unstemmed Impact of Cold Ischemia Time on Outcomes of Deceased Donor Kidney Transplantation: An Analysis of a National Registry
title_short Impact of Cold Ischemia Time on Outcomes of Deceased Donor Kidney Transplantation: An Analysis of a National Registry
title_sort impact of cold ischemia time on outcomes of deceased donor kidney transplantation: an analysis of a national registry
topic Kidney Transplantation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511440/
https://www.ncbi.nlm.nih.gov/pubmed/31165083
http://dx.doi.org/10.1097/TXD.0000000000000888
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