Cargando…
Longitudinal follow-up of two patients with isolated paracentral acute middle maculopathy
Objective: To describe longitudinal retinal changes in two cases of isolated paracentral acute middle maculopathy (PAMM). Case series: We reported two cases (64 and 67-year-old men) with isolated PAMM, who were followed-up for over 5 and 2.5 years, respectively. Both cases exhibited similar clinical...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511651/ https://www.ncbi.nlm.nih.gov/pubmed/31191041 http://dx.doi.org/10.2147/IMCRJ.S196047 |
_version_ | 1783417603054632960 |
---|---|
author | Nakamura, Masaki Katagiri, Satoshi Hayashi, Takaaki Aoyagi, Ranko Hasegawa, Taiji Kogure, Akiko Iida, Tomohiro Nakano, Tadashi |
author_facet | Nakamura, Masaki Katagiri, Satoshi Hayashi, Takaaki Aoyagi, Ranko Hasegawa, Taiji Kogure, Akiko Iida, Tomohiro Nakano, Tadashi |
author_sort | Nakamura, Masaki |
collection | PubMed |
description | Objective: To describe longitudinal retinal changes in two cases of isolated paracentral acute middle maculopathy (PAMM). Case series: We reported two cases (64 and 67-year-old men) with isolated PAMM, who were followed-up for over 5 and 2.5 years, respectively. Both cases exhibited similar clinical natural histories. The first examinations took place several days after onset, with funduscopy showing that both cases exhibited paracentral scotoma with good visual acuity and small gray lesions, while optical coherence tomography (OCT) showed the presence of a hyperreflective band that ranged from the inner plexiform layer to the outer plexiform layer (OPL). The lesions became unremarkable within 1 month. The hyperreflective band also became unremarkable and was limited to the inner nuclear layer (INL) within 1 month, with the band disappearing within several months. Subsequently, OCT showed there was a thin and irregular INL and OPL, an excavated change of the inner retinal surface, along with outer nuclear layer (ONL) thickening. After several years, OCT angiography demonstrated normal flow of macular capillaries in the superficial capillary plexus, and decreased flow in the lesion with dilation of the capillaries around the area in the deep capillary plexus (DCP). Focal serous retinal detachment (SRD) occurred in one case after 4–5 years. Conclusion: Our findings indicated that long-term retinal changes in PAMM resulted in excavation of the inner retinal surface, INL thinning, ONL thickening and abnormal vasculature, especially in the DCP. Focal SRD may be a rare complication that can present at 4 years after onset. |
format | Online Article Text |
id | pubmed-6511651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-65116512019-06-12 Longitudinal follow-up of two patients with isolated paracentral acute middle maculopathy Nakamura, Masaki Katagiri, Satoshi Hayashi, Takaaki Aoyagi, Ranko Hasegawa, Taiji Kogure, Akiko Iida, Tomohiro Nakano, Tadashi Int Med Case Rep J Case Series Objective: To describe longitudinal retinal changes in two cases of isolated paracentral acute middle maculopathy (PAMM). Case series: We reported two cases (64 and 67-year-old men) with isolated PAMM, who were followed-up for over 5 and 2.5 years, respectively. Both cases exhibited similar clinical natural histories. The first examinations took place several days after onset, with funduscopy showing that both cases exhibited paracentral scotoma with good visual acuity and small gray lesions, while optical coherence tomography (OCT) showed the presence of a hyperreflective band that ranged from the inner plexiform layer to the outer plexiform layer (OPL). The lesions became unremarkable within 1 month. The hyperreflective band also became unremarkable and was limited to the inner nuclear layer (INL) within 1 month, with the band disappearing within several months. Subsequently, OCT showed there was a thin and irregular INL and OPL, an excavated change of the inner retinal surface, along with outer nuclear layer (ONL) thickening. After several years, OCT angiography demonstrated normal flow of macular capillaries in the superficial capillary plexus, and decreased flow in the lesion with dilation of the capillaries around the area in the deep capillary plexus (DCP). Focal serous retinal detachment (SRD) occurred in one case after 4–5 years. Conclusion: Our findings indicated that long-term retinal changes in PAMM resulted in excavation of the inner retinal surface, INL thinning, ONL thickening and abnormal vasculature, especially in the DCP. Focal SRD may be a rare complication that can present at 4 years after onset. Dove 2019-05-06 /pmc/articles/PMC6511651/ /pubmed/31191041 http://dx.doi.org/10.2147/IMCRJ.S196047 Text en © 2019 Nakamura et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Case Series Nakamura, Masaki Katagiri, Satoshi Hayashi, Takaaki Aoyagi, Ranko Hasegawa, Taiji Kogure, Akiko Iida, Tomohiro Nakano, Tadashi Longitudinal follow-up of two patients with isolated paracentral acute middle maculopathy |
title | Longitudinal follow-up of two patients with isolated paracentral acute middle maculopathy |
title_full | Longitudinal follow-up of two patients with isolated paracentral acute middle maculopathy |
title_fullStr | Longitudinal follow-up of two patients with isolated paracentral acute middle maculopathy |
title_full_unstemmed | Longitudinal follow-up of two patients with isolated paracentral acute middle maculopathy |
title_short | Longitudinal follow-up of two patients with isolated paracentral acute middle maculopathy |
title_sort | longitudinal follow-up of two patients with isolated paracentral acute middle maculopathy |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511651/ https://www.ncbi.nlm.nih.gov/pubmed/31191041 http://dx.doi.org/10.2147/IMCRJ.S196047 |
work_keys_str_mv | AT nakamuramasaki longitudinalfollowupoftwopatientswithisolatedparacentralacutemiddlemaculopathy AT katagirisatoshi longitudinalfollowupoftwopatientswithisolatedparacentralacutemiddlemaculopathy AT hayashitakaaki longitudinalfollowupoftwopatientswithisolatedparacentralacutemiddlemaculopathy AT aoyagiranko longitudinalfollowupoftwopatientswithisolatedparacentralacutemiddlemaculopathy AT hasegawataiji longitudinalfollowupoftwopatientswithisolatedparacentralacutemiddlemaculopathy AT kogureakiko longitudinalfollowupoftwopatientswithisolatedparacentralacutemiddlemaculopathy AT iidatomohiro longitudinalfollowupoftwopatientswithisolatedparacentralacutemiddlemaculopathy AT nakanotadashi longitudinalfollowupoftwopatientswithisolatedparacentralacutemiddlemaculopathy |