CSF Protein Concentration Shows No Correlation With Brain Volume Measures

Background: CSF protein concentrations vary greatly among individuals. Accounting for brain volume may lower the variance and increase the diagnostic value of CSF protein concentrations. Objective: To determine the relation between CSF protein concentrations and brain volume. Methods: Brain volumes...

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Autores principales: Wuschek, Alexander, Grahl, Sophia, Pongratz, Viola, Korn, Thomas, Kirschke, Jan, Zimmer, Claus, Hemmer, Bernhard, Mühlau, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511809/
https://www.ncbi.nlm.nih.gov/pubmed/31133968
http://dx.doi.org/10.3389/fneur.2019.00463
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author Wuschek, Alexander
Grahl, Sophia
Pongratz, Viola
Korn, Thomas
Kirschke, Jan
Zimmer, Claus
Hemmer, Bernhard
Mühlau, Mark
author_facet Wuschek, Alexander
Grahl, Sophia
Pongratz, Viola
Korn, Thomas
Kirschke, Jan
Zimmer, Claus
Hemmer, Bernhard
Mühlau, Mark
author_sort Wuschek, Alexander
collection PubMed
description Background: CSF protein concentrations vary greatly among individuals. Accounting for brain volume may lower the variance and increase the diagnostic value of CSF protein concentrations. Objective: To determine the relation between CSF protein concentrations and brain volume. Methods: Brain volumes (total intracranial, gray matter, white matter volumes) derived from brain MRI and CSF protein concentrations (total protein, albumin, albumin CSF/serum ratio) of 29 control patients and 497 patients with clinically isolated syndrome or multiple sclerosis were studied. Finding: We found significant positive correlations of CSF protein concentrations with intracranial, gray matter, and white matter volumes. None of the correlations remained significant after correction for age and sex. Conclusion: Accounting for brain volume derived from brain MRI is unlikely to improve the diagnostic value of protein concentrations in CSF.
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spelling pubmed-65118092019-05-27 CSF Protein Concentration Shows No Correlation With Brain Volume Measures Wuschek, Alexander Grahl, Sophia Pongratz, Viola Korn, Thomas Kirschke, Jan Zimmer, Claus Hemmer, Bernhard Mühlau, Mark Front Neurol Neurology Background: CSF protein concentrations vary greatly among individuals. Accounting for brain volume may lower the variance and increase the diagnostic value of CSF protein concentrations. Objective: To determine the relation between CSF protein concentrations and brain volume. Methods: Brain volumes (total intracranial, gray matter, white matter volumes) derived from brain MRI and CSF protein concentrations (total protein, albumin, albumin CSF/serum ratio) of 29 control patients and 497 patients with clinically isolated syndrome or multiple sclerosis were studied. Finding: We found significant positive correlations of CSF protein concentrations with intracranial, gray matter, and white matter volumes. None of the correlations remained significant after correction for age and sex. Conclusion: Accounting for brain volume derived from brain MRI is unlikely to improve the diagnostic value of protein concentrations in CSF. Frontiers Media S.A. 2019-05-03 /pmc/articles/PMC6511809/ /pubmed/31133968 http://dx.doi.org/10.3389/fneur.2019.00463 Text en Copyright © 2019 Wuschek, Grahl, Pongratz, Korn, Kirschke, Zimmer, Hemmer and Mühlau. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Wuschek, Alexander
Grahl, Sophia
Pongratz, Viola
Korn, Thomas
Kirschke, Jan
Zimmer, Claus
Hemmer, Bernhard
Mühlau, Mark
CSF Protein Concentration Shows No Correlation With Brain Volume Measures
title CSF Protein Concentration Shows No Correlation With Brain Volume Measures
title_full CSF Protein Concentration Shows No Correlation With Brain Volume Measures
title_fullStr CSF Protein Concentration Shows No Correlation With Brain Volume Measures
title_full_unstemmed CSF Protein Concentration Shows No Correlation With Brain Volume Measures
title_short CSF Protein Concentration Shows No Correlation With Brain Volume Measures
title_sort csf protein concentration shows no correlation with brain volume measures
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511809/
https://www.ncbi.nlm.nih.gov/pubmed/31133968
http://dx.doi.org/10.3389/fneur.2019.00463
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