De-ubiquitination of ELK-1 by USP17 potentiates mitogenic gene expression and cell proliferation

ELK-1 is a transcription factor involved in ERK-induced cellular proliferation. Here, we show that its transcriptional activity is modulated by ubiquitination at lysine 35 (K35). The level of ubiquitinated ELK-1 rises in mitogen-deprived cells and falls upon mitogen stimulation or oncogene expressio...

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Detalles Bibliográficos
Autores principales: Ducker, Charles, Chow, Leo Kam Yuen, Saxton, Janice, Handwerger, Jürgen, McGregor, Alexander, Strahl, Thomas, Layfield, Robert, Shaw, Peter E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511843/
https://www.ncbi.nlm.nih.gov/pubmed/30854565
http://dx.doi.org/10.1093/nar/gkz166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511843/
https://www.ncbi.nlm.nih.gov/pubmed/30854565
http://dx.doi.org/10.1093/nar/gkz166

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