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Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines

Antisense oligonucleotides (ASOs) modulate cellular target gene expression through direct binding to complementary RNA. Advances in ASO chemistry have led to the development of phosphorothioate (PS) ASOs with constrained-ethyl modifications (cEt). These next-generation cEt-ASOs can enter cells witho...

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Detalles Bibliográficos
Autores principales:	Linnane, Emily, Davey, Paul, Zhang, Pei, Puri, Sanyogitta, Edbrooke, Mark, Chiarparin, Elisabetta, Revenko, Alexey S, Macleod, A Robert, Norman, Jim C, Ross, Sarah J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511877/ https://www.ncbi.nlm.nih.gov/pubmed/30927008 http://dx.doi.org/10.1093/nar/gkz214

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