Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug

[Image: see text] Expression of β-lactamase is the single most prevalent determinant of antibiotic resistance, rendering bacteria resistant to β-lactam antibiotics. In this article, we describe the development of an antibiotic prodrug that combines ciprofloxacin with a β-lactamase-cleavable motif. T...

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Detalles Bibliográficos
Autores principales: Evans, Lindsay E., Krishna, Aishwarya, Ma, Yajing, Webb, Thomas E., Marshall, Dominic C., Tooke, Catherine L., Spencer, James, Clarke, Thomas B., Armstrong, Alan, Edwards, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511942/
https://www.ncbi.nlm.nih.gov/pubmed/31009558
http://dx.doi.org/10.1021/acs.jmedchem.8b01923

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