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High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor

[Image: see text] Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an intracellular enzyme that helps generate peptides presented by Major Histocompatibility Complex Class I (MHC class I) molecules and is an emerging target for immunotherapy applications. Despite almost two decades of research on E...

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Detalles Bibliográficos
Autores principales: Giastas, Petros, Neu, Margarete, Rowland, Paul, Stratikos, Efstratios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511960/
https://www.ncbi.nlm.nih.gov/pubmed/31097987
http://dx.doi.org/10.1021/acsmedchemlett.9b00002

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