Cargando…
Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis
RANKL (receptor activator of nuclear factor kappa-β ligand) and OPG (osteoprotegerin) are two proteins involved in bone remodelling. During the active phase of periodontal disease, an imbalance between the ratios of the two elements can be noticed. While the expression of RANKL is elevated compared...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512014/ https://www.ncbi.nlm.nih.gov/pubmed/31183390 http://dx.doi.org/10.1155/2019/6195258 |
_version_ | 1783417629926490112 |
---|---|
author | Teodorescu, Alexandra Cornelia Martu, Ioana Teslaru, Silvia Kappenberg-Nitescu, Diana Cristala Goriuc, Ancuta Luchian, Ionut Martu, Maria Alexandra Solomon, Sorina Mihaela Mârțu, Silvia |
author_facet | Teodorescu, Alexandra Cornelia Martu, Ioana Teslaru, Silvia Kappenberg-Nitescu, Diana Cristala Goriuc, Ancuta Luchian, Ionut Martu, Maria Alexandra Solomon, Sorina Mihaela Mârțu, Silvia |
author_sort | Teodorescu, Alexandra Cornelia |
collection | PubMed |
description | RANKL (receptor activator of nuclear factor kappa-β ligand) and OPG (osteoprotegerin) are two proteins involved in bone remodelling. During the active phase of periodontal disease, an imbalance between the ratios of the two elements can be noticed. While the expression of RANKL is elevated compared with that of OPG, the RANKL is available to bond with RANK (receptor activator of nuclear factor kappa-β). This study was conducted on 41 patients: 19 with generalized aggressive periodontitis, 18 with severe chronic periodontitis, and 4 periodontal healthy subjects. For each patient included, we determined the salivary levels of RANKL and OPG with the help of two Human ELISA kits. The results show that the patients affected by periodontitis, either aggressive or chronic, have significant higher values of RANKL and RANKL/OPG ratio. This values correlate with the local inflammation status. |
format | Online Article Text |
id | pubmed-6512014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-65120142019-06-10 Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis Teodorescu, Alexandra Cornelia Martu, Ioana Teslaru, Silvia Kappenberg-Nitescu, Diana Cristala Goriuc, Ancuta Luchian, Ionut Martu, Maria Alexandra Solomon, Sorina Mihaela Mârțu, Silvia J Immunol Res Research Article RANKL (receptor activator of nuclear factor kappa-β ligand) and OPG (osteoprotegerin) are two proteins involved in bone remodelling. During the active phase of periodontal disease, an imbalance between the ratios of the two elements can be noticed. While the expression of RANKL is elevated compared with that of OPG, the RANKL is available to bond with RANK (receptor activator of nuclear factor kappa-β). This study was conducted on 41 patients: 19 with generalized aggressive periodontitis, 18 with severe chronic periodontitis, and 4 periodontal healthy subjects. For each patient included, we determined the salivary levels of RANKL and OPG with the help of two Human ELISA kits. The results show that the patients affected by periodontitis, either aggressive or chronic, have significant higher values of RANKL and RANKL/OPG ratio. This values correlate with the local inflammation status. Hindawi 2019-04-28 /pmc/articles/PMC6512014/ /pubmed/31183390 http://dx.doi.org/10.1155/2019/6195258 Text en Copyright © 2019 Alexandra Cornelia Teodorescu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Teodorescu, Alexandra Cornelia Martu, Ioana Teslaru, Silvia Kappenberg-Nitescu, Diana Cristala Goriuc, Ancuta Luchian, Ionut Martu, Maria Alexandra Solomon, Sorina Mihaela Mârțu, Silvia Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis |
title | Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis |
title_full | Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis |
title_fullStr | Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis |
title_full_unstemmed | Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis |
title_short | Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis |
title_sort | assessment of salivary levels of rankl and opg in aggressive versus chronic periodontitis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512014/ https://www.ncbi.nlm.nih.gov/pubmed/31183390 http://dx.doi.org/10.1155/2019/6195258 |
work_keys_str_mv | AT teodorescualexandracornelia assessmentofsalivarylevelsofranklandopginaggressiveversuschronicperiodontitis AT martuioana assessmentofsalivarylevelsofranklandopginaggressiveversuschronicperiodontitis AT teslarusilvia assessmentofsalivarylevelsofranklandopginaggressiveversuschronicperiodontitis AT kappenbergnitescudianacristala assessmentofsalivarylevelsofranklandopginaggressiveversuschronicperiodontitis AT goriucancuta assessmentofsalivarylevelsofranklandopginaggressiveversuschronicperiodontitis AT luchianionut assessmentofsalivarylevelsofranklandopginaggressiveversuschronicperiodontitis AT martumariaalexandra assessmentofsalivarylevelsofranklandopginaggressiveversuschronicperiodontitis AT solomonsorinamihaela assessmentofsalivarylevelsofranklandopginaggressiveversuschronicperiodontitis AT martusilvia assessmentofsalivarylevelsofranklandopginaggressiveversuschronicperiodontitis |