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Aberrant Expression of Collagen Gene Family in the Brain Regions of Male Mice with Behavioral Psychopathologies Induced by Chronic Agonistic Interactions

Chronic agonistic interactions promote the development of experimental psychopathologies in animals: a depression-like state in chronically defeated mice and the pathology of aggressive behavior in the mice with repeated wins. The abundant research data indicate that such psychopathological states a...

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Autores principales: Smagin, Dmitry A., Galyamina, Anna G., Kovalenko, Irina L., Babenko, Vladimir N., Kudryavtseva, Natalia N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512038/
https://www.ncbi.nlm.nih.gov/pubmed/31183373
http://dx.doi.org/10.1155/2019/7276389
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author Smagin, Dmitry A.
Galyamina, Anna G.
Kovalenko, Irina L.
Babenko, Vladimir N.
Kudryavtseva, Natalia N.
author_facet Smagin, Dmitry A.
Galyamina, Anna G.
Kovalenko, Irina L.
Babenko, Vladimir N.
Kudryavtseva, Natalia N.
author_sort Smagin, Dmitry A.
collection PubMed
description Chronic agonistic interactions promote the development of experimental psychopathologies in animals: a depression-like state in chronically defeated mice and the pathology of aggressive behavior in the mice with repeated wins. The abundant research data indicate that such psychopathological states are associated with significant molecular and cellular changes in the brain. This paper aims to study the influence of a 20-day period of agonistic interactions on the expression patterns of collagen family genes encoding the proteins which are basic components of extracellular matrix (ECM) in different brain regions of mice using the RNA-Seq database. Most of differentially expressed collagen genes were shown to be upregulated in the hypothalamus and striatum of chronically aggressive and defeated mice and in the hippocampus of defeated mice, whereas downregulation of collagen genes was demonstrated in the ventral tegmental areas in both experimental groups. Aberrant expression of collagen genes induced by chronic agonistic interactions may be indicative of specific ECM defects in the brain regions of mice with alternative social experience. This is the first study demonstrating remodeling of ECM under the development of experimental disorders.
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spelling pubmed-65120382019-06-10 Aberrant Expression of Collagen Gene Family in the Brain Regions of Male Mice with Behavioral Psychopathologies Induced by Chronic Agonistic Interactions Smagin, Dmitry A. Galyamina, Anna G. Kovalenko, Irina L. Babenko, Vladimir N. Kudryavtseva, Natalia N. Biomed Res Int Research Article Chronic agonistic interactions promote the development of experimental psychopathologies in animals: a depression-like state in chronically defeated mice and the pathology of aggressive behavior in the mice with repeated wins. The abundant research data indicate that such psychopathological states are associated with significant molecular and cellular changes in the brain. This paper aims to study the influence of a 20-day period of agonistic interactions on the expression patterns of collagen family genes encoding the proteins which are basic components of extracellular matrix (ECM) in different brain regions of mice using the RNA-Seq database. Most of differentially expressed collagen genes were shown to be upregulated in the hypothalamus and striatum of chronically aggressive and defeated mice and in the hippocampus of defeated mice, whereas downregulation of collagen genes was demonstrated in the ventral tegmental areas in both experimental groups. Aberrant expression of collagen genes induced by chronic agonistic interactions may be indicative of specific ECM defects in the brain regions of mice with alternative social experience. This is the first study demonstrating remodeling of ECM under the development of experimental disorders. Hindawi 2019-04-28 /pmc/articles/PMC6512038/ /pubmed/31183373 http://dx.doi.org/10.1155/2019/7276389 Text en Copyright © 2019 Dmitry A. Smagin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Smagin, Dmitry A.
Galyamina, Anna G.
Kovalenko, Irina L.
Babenko, Vladimir N.
Kudryavtseva, Natalia N.
Aberrant Expression of Collagen Gene Family in the Brain Regions of Male Mice with Behavioral Psychopathologies Induced by Chronic Agonistic Interactions
title Aberrant Expression of Collagen Gene Family in the Brain Regions of Male Mice with Behavioral Psychopathologies Induced by Chronic Agonistic Interactions
title_full Aberrant Expression of Collagen Gene Family in the Brain Regions of Male Mice with Behavioral Psychopathologies Induced by Chronic Agonistic Interactions
title_fullStr Aberrant Expression of Collagen Gene Family in the Brain Regions of Male Mice with Behavioral Psychopathologies Induced by Chronic Agonistic Interactions
title_full_unstemmed Aberrant Expression of Collagen Gene Family in the Brain Regions of Male Mice with Behavioral Psychopathologies Induced by Chronic Agonistic Interactions
title_short Aberrant Expression of Collagen Gene Family in the Brain Regions of Male Mice with Behavioral Psychopathologies Induced by Chronic Agonistic Interactions
title_sort aberrant expression of collagen gene family in the brain regions of male mice with behavioral psychopathologies induced by chronic agonistic interactions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512038/
https://www.ncbi.nlm.nih.gov/pubmed/31183373
http://dx.doi.org/10.1155/2019/7276389
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