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Abnormal DNA Methylation Induced by Hyperglycemia Reduces CXCR4 Gene Expression in CD34(+) Stem Cells

BACKGROUND: CD34(+) stem/progenitor cells are involved in vascular homeostasis and in neovascularization of ischemic tissues. The number of circulating CD34(+) stem cells is a predictive biomarker of adverse cardiovascular outcomes in diabetic patients. Here, we provide evidence that hyperglycemia c...

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Detalles Bibliográficos
Autores principales:	Vigorelli, Vera, Resta, Jessica, Bianchessi, Valentina, Lauri, Andrea, Bassetti, Beatrice, Agrifoglio, Marco, Pesce, Maurizio, Polvani, Gianluca, Bonalumi, Giorgia, Cavallotti, Laura, Alamanni, Francesco, Genovese, Stefano, Pompilio, Giulio, Vinci, Maria Cristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512087/ https://www.ncbi.nlm.nih.gov/pubmed/31018749 http://dx.doi.org/10.1161/JAHA.118.010012

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