Cargando…

Low‐Carbohydrate Diets and Risk of Incident Atrial Fibrillation: A Prospective Cohort Study

BACKGROUND: The influences of low‐carbohydrate diets in cardiovascular disease are controversial. Few studies have examined the relationship of carbohydrate intake and risk of incident atrial fibrillation (AF). We aimed to evaluate the association between carbohydrate intake and the risk of incident...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Shaozhao, Zhuang, Xiaodong, Lin, Xiaoyu, Zhong, Xiangbin, Zhou, Huimin, Sun, Xiuting, Xiong, Zhenyu, Huang, Yiquan, Fan, Yongqiang, Guo, Yue, Du, Zhimin, Liao, Xinxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512089/
https://www.ncbi.nlm.nih.gov/pubmed/31020911
http://dx.doi.org/10.1161/JAHA.119.011955
_version_ 1783417647428272128
author Zhang, Shaozhao
Zhuang, Xiaodong
Lin, Xiaoyu
Zhong, Xiangbin
Zhou, Huimin
Sun, Xiuting
Xiong, Zhenyu
Huang, Yiquan
Fan, Yongqiang
Guo, Yue
Du, Zhimin
Liao, Xinxue
author_facet Zhang, Shaozhao
Zhuang, Xiaodong
Lin, Xiaoyu
Zhong, Xiangbin
Zhou, Huimin
Sun, Xiuting
Xiong, Zhenyu
Huang, Yiquan
Fan, Yongqiang
Guo, Yue
Du, Zhimin
Liao, Xinxue
author_sort Zhang, Shaozhao
collection PubMed
description BACKGROUND: The influences of low‐carbohydrate diets in cardiovascular disease are controversial. Few studies have examined the relationship of carbohydrate intake and risk of incident atrial fibrillation (AF). We aimed to evaluate the association between carbohydrate intake and the risk of incident AF in the ARIC (Atherosclerosis Risk in Communities) Study. METHODS AND RESULTS: We included 13 385 participants (age, 54.2±5.8 years; 45.1% men and 74.7% white) who completed a dietary questionnaire at baseline (1987–1989) in the ARIC Study. The primary outcome was incident AF, which was identified by ECG performed during study examinations, hospital discharge codes, and death certificates. We used multivariable Cox hazard regression models to assess the association between carbohydrate intake and incident AF. We further explored the effects of specific food source (animal versus plant based) used to replace carbohydrate intake in the low‐carbohydrate intake setting. During a median follow‐up of 22.4 years, 1808 cases (13.5%) of AF occurred. The hazard ratio for incident AF associated with a 1‐SD (9.4%) increase in carbohydrate intake as a percentage of energy intake was 0.82 (95% CI, 0.72–0.94), after adjustment for traditional AF risk factors and other diets factors. Results were similar when individuals were categorized by carbohydrate intake quartiles (hazard ratio, 0.64; 95% CI, 0.49–0.84; comparing extreme quartiles). No association was found between the type of protein or fat used to replace the carbohydrate and risk of incident AF. CONCLUSIONS: Low‐carbohydrate diets were associated with increased risk of incident AF, regardless of the type of protein or fat used to replace the carbohydrate.
format Online
Article
Text
id pubmed-6512089
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-65120892019-05-20 Low‐Carbohydrate Diets and Risk of Incident Atrial Fibrillation: A Prospective Cohort Study Zhang, Shaozhao Zhuang, Xiaodong Lin, Xiaoyu Zhong, Xiangbin Zhou, Huimin Sun, Xiuting Xiong, Zhenyu Huang, Yiquan Fan, Yongqiang Guo, Yue Du, Zhimin Liao, Xinxue J Am Heart Assoc Original Research BACKGROUND: The influences of low‐carbohydrate diets in cardiovascular disease are controversial. Few studies have examined the relationship of carbohydrate intake and risk of incident atrial fibrillation (AF). We aimed to evaluate the association between carbohydrate intake and the risk of incident AF in the ARIC (Atherosclerosis Risk in Communities) Study. METHODS AND RESULTS: We included 13 385 participants (age, 54.2±5.8 years; 45.1% men and 74.7% white) who completed a dietary questionnaire at baseline (1987–1989) in the ARIC Study. The primary outcome was incident AF, which was identified by ECG performed during study examinations, hospital discharge codes, and death certificates. We used multivariable Cox hazard regression models to assess the association between carbohydrate intake and incident AF. We further explored the effects of specific food source (animal versus plant based) used to replace carbohydrate intake in the low‐carbohydrate intake setting. During a median follow‐up of 22.4 years, 1808 cases (13.5%) of AF occurred. The hazard ratio for incident AF associated with a 1‐SD (9.4%) increase in carbohydrate intake as a percentage of energy intake was 0.82 (95% CI, 0.72–0.94), after adjustment for traditional AF risk factors and other diets factors. Results were similar when individuals were categorized by carbohydrate intake quartiles (hazard ratio, 0.64; 95% CI, 0.49–0.84; comparing extreme quartiles). No association was found between the type of protein or fat used to replace the carbohydrate and risk of incident AF. CONCLUSIONS: Low‐carbohydrate diets were associated with increased risk of incident AF, regardless of the type of protein or fat used to replace the carbohydrate. John Wiley and Sons Inc. 2019-04-25 /pmc/articles/PMC6512089/ /pubmed/31020911 http://dx.doi.org/10.1161/JAHA.119.011955 Text en © 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Zhang, Shaozhao
Zhuang, Xiaodong
Lin, Xiaoyu
Zhong, Xiangbin
Zhou, Huimin
Sun, Xiuting
Xiong, Zhenyu
Huang, Yiquan
Fan, Yongqiang
Guo, Yue
Du, Zhimin
Liao, Xinxue
Low‐Carbohydrate Diets and Risk of Incident Atrial Fibrillation: A Prospective Cohort Study
title Low‐Carbohydrate Diets and Risk of Incident Atrial Fibrillation: A Prospective Cohort Study
title_full Low‐Carbohydrate Diets and Risk of Incident Atrial Fibrillation: A Prospective Cohort Study
title_fullStr Low‐Carbohydrate Diets and Risk of Incident Atrial Fibrillation: A Prospective Cohort Study
title_full_unstemmed Low‐Carbohydrate Diets and Risk of Incident Atrial Fibrillation: A Prospective Cohort Study
title_short Low‐Carbohydrate Diets and Risk of Incident Atrial Fibrillation: A Prospective Cohort Study
title_sort low‐carbohydrate diets and risk of incident atrial fibrillation: a prospective cohort study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512089/
https://www.ncbi.nlm.nih.gov/pubmed/31020911
http://dx.doi.org/10.1161/JAHA.119.011955
work_keys_str_mv AT zhangshaozhao lowcarbohydratedietsandriskofincidentatrialfibrillationaprospectivecohortstudy
AT zhuangxiaodong lowcarbohydratedietsandriskofincidentatrialfibrillationaprospectivecohortstudy
AT linxiaoyu lowcarbohydratedietsandriskofincidentatrialfibrillationaprospectivecohortstudy
AT zhongxiangbin lowcarbohydratedietsandriskofincidentatrialfibrillationaprospectivecohortstudy
AT zhouhuimin lowcarbohydratedietsandriskofincidentatrialfibrillationaprospectivecohortstudy
AT sunxiuting lowcarbohydratedietsandriskofincidentatrialfibrillationaprospectivecohortstudy
AT xiongzhenyu lowcarbohydratedietsandriskofincidentatrialfibrillationaprospectivecohortstudy
AT huangyiquan lowcarbohydratedietsandriskofincidentatrialfibrillationaprospectivecohortstudy
AT fanyongqiang lowcarbohydratedietsandriskofincidentatrialfibrillationaprospectivecohortstudy
AT guoyue lowcarbohydratedietsandriskofincidentatrialfibrillationaprospectivecohortstudy
AT duzhimin lowcarbohydratedietsandriskofincidentatrialfibrillationaprospectivecohortstudy
AT liaoxinxue lowcarbohydratedietsandriskofincidentatrialfibrillationaprospectivecohortstudy