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Prognostic Implications of Door‐to‐Balloon Time and Onset‐to‐Door Time on Mortality in Patients With ST‐Segment–Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention
BACKGROUND: In patients with ST‐segment–elevation myocardial infarction, timely reperfusion therapy with door‐to‐balloon (D2B) time <90 minutes is recommended by the current guidelines. However, whether further shortening of symptom onset‐to‐door (O2D) time or D2B time would enhance survival of p...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512115/ https://www.ncbi.nlm.nih.gov/pubmed/31041869 http://dx.doi.org/10.1161/JAHA.119.012188 |
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author | Park, Jonghanne Choi, Ki Hong Lee, Joo Myung Kim, Hyun Kuk Hwang, Doyeon Rhee, Tae‐Min Kim, Jihoon Park, Taek Kyu Yang, Jeong Hoon Song, Young Bin Choi, Jin‐Ho Hahn, Joo‐Yong Choi, Seung‐Hyuk Koo, Bon‐Kwon Chae, Shung Chull Cho, Myeong Chan Kim, Chong Jin Kim, Ju Han Jeong, Myung Ho Gwon, Hyeon‐Cheol Kim, Hyo‐Soo |
author_facet | Park, Jonghanne Choi, Ki Hong Lee, Joo Myung Kim, Hyun Kuk Hwang, Doyeon Rhee, Tae‐Min Kim, Jihoon Park, Taek Kyu Yang, Jeong Hoon Song, Young Bin Choi, Jin‐Ho Hahn, Joo‐Yong Choi, Seung‐Hyuk Koo, Bon‐Kwon Chae, Shung Chull Cho, Myeong Chan Kim, Chong Jin Kim, Ju Han Jeong, Myung Ho Gwon, Hyeon‐Cheol Kim, Hyo‐Soo |
author_sort | Park, Jonghanne |
collection | PubMed |
description | BACKGROUND: In patients with ST‐segment–elevation myocardial infarction, timely reperfusion therapy with door‐to‐balloon (D2B) time <90 minutes is recommended by the current guidelines. However, whether further shortening of symptom onset‐to‐door (O2D) time or D2B time would enhance survival of patients with ST‐segment–elevation myocardial infarction remains unclear. Therefore, the current study aimed to evaluate the prognostic impact of O2D or D2B time in patients with ST‐segment–elevation myocardial infarction who underwent primary percutaneous coronary intervention. METHODS AND RESULTS: We analyzed 5243 patients with ST‐segment–elevation myocardial infarction were treated at 20 tertiary hospitals capable of primary percutaneous coronary intervention in Korea. The association between O2D or D2B time with all‐cause mortality at 1 year was evaluated. The median O2D time was 2.0 hours, and the median D2B time was 59 minutes. A total of 92.2% of the total population showed D2B time ≤90 minutes. In univariable analysis, 1‐hour delay of D2B time was associated with a 55% increased 1‐year mortality, whereas 1‐hour delay of O2D time was associated with a 4% increased 1‐year mortality. In multivariable analysis, D2B time showed an independent association with mortality (adjusted hazard ratio, 1.90; 95% CI, 1.51–2.39; P<0.001). Reducing D2B time within 45 minutes showed further decreased risk of mortality compared with D2B time >90 minutes (adjusted hazard ratio, 0.30; 95% CI, 0.19–0.42; P<0.001). Every reduction of D2B time by 30 minutes showed continuous reduction of 1‐year mortality (90 to 60 minutes: absolute risk reduction, 2.4%; number needed to treat, 41.9; 60 to 30 minutes: absolute risk reduction, 2.0%; number needed to treat, 49.2). CONCLUSIONS: Shortening D2B time was significantly associated with survival benefit, and the survival benefit of shortening D2B time was consistently observed, even <60 to 90 minutes. |
format | Online Article Text |
id | pubmed-6512115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65121152019-05-20 Prognostic Implications of Door‐to‐Balloon Time and Onset‐to‐Door Time on Mortality in Patients With ST‐Segment–Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention Park, Jonghanne Choi, Ki Hong Lee, Joo Myung Kim, Hyun Kuk Hwang, Doyeon Rhee, Tae‐Min Kim, Jihoon Park, Taek Kyu Yang, Jeong Hoon Song, Young Bin Choi, Jin‐Ho Hahn, Joo‐Yong Choi, Seung‐Hyuk Koo, Bon‐Kwon Chae, Shung Chull Cho, Myeong Chan Kim, Chong Jin Kim, Ju Han Jeong, Myung Ho Gwon, Hyeon‐Cheol Kim, Hyo‐Soo J Am Heart Assoc Original Research BACKGROUND: In patients with ST‐segment–elevation myocardial infarction, timely reperfusion therapy with door‐to‐balloon (D2B) time <90 minutes is recommended by the current guidelines. However, whether further shortening of symptom onset‐to‐door (O2D) time or D2B time would enhance survival of patients with ST‐segment–elevation myocardial infarction remains unclear. Therefore, the current study aimed to evaluate the prognostic impact of O2D or D2B time in patients with ST‐segment–elevation myocardial infarction who underwent primary percutaneous coronary intervention. METHODS AND RESULTS: We analyzed 5243 patients with ST‐segment–elevation myocardial infarction were treated at 20 tertiary hospitals capable of primary percutaneous coronary intervention in Korea. The association between O2D or D2B time with all‐cause mortality at 1 year was evaluated. The median O2D time was 2.0 hours, and the median D2B time was 59 minutes. A total of 92.2% of the total population showed D2B time ≤90 minutes. In univariable analysis, 1‐hour delay of D2B time was associated with a 55% increased 1‐year mortality, whereas 1‐hour delay of O2D time was associated with a 4% increased 1‐year mortality. In multivariable analysis, D2B time showed an independent association with mortality (adjusted hazard ratio, 1.90; 95% CI, 1.51–2.39; P<0.001). Reducing D2B time within 45 minutes showed further decreased risk of mortality compared with D2B time >90 minutes (adjusted hazard ratio, 0.30; 95% CI, 0.19–0.42; P<0.001). Every reduction of D2B time by 30 minutes showed continuous reduction of 1‐year mortality (90 to 60 minutes: absolute risk reduction, 2.4%; number needed to treat, 41.9; 60 to 30 minutes: absolute risk reduction, 2.0%; number needed to treat, 49.2). CONCLUSIONS: Shortening D2B time was significantly associated with survival benefit, and the survival benefit of shortening D2B time was consistently observed, even <60 to 90 minutes. John Wiley and Sons Inc. 2019-05-01 /pmc/articles/PMC6512115/ /pubmed/31041869 http://dx.doi.org/10.1161/JAHA.119.012188 Text en © 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Research Park, Jonghanne Choi, Ki Hong Lee, Joo Myung Kim, Hyun Kuk Hwang, Doyeon Rhee, Tae‐Min Kim, Jihoon Park, Taek Kyu Yang, Jeong Hoon Song, Young Bin Choi, Jin‐Ho Hahn, Joo‐Yong Choi, Seung‐Hyuk Koo, Bon‐Kwon Chae, Shung Chull Cho, Myeong Chan Kim, Chong Jin Kim, Ju Han Jeong, Myung Ho Gwon, Hyeon‐Cheol Kim, Hyo‐Soo Prognostic Implications of Door‐to‐Balloon Time and Onset‐to‐Door Time on Mortality in Patients With ST‐Segment–Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention |
title | Prognostic Implications of Door‐to‐Balloon Time and Onset‐to‐Door Time on Mortality in Patients With ST‐Segment–Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention |
title_full | Prognostic Implications of Door‐to‐Balloon Time and Onset‐to‐Door Time on Mortality in Patients With ST‐Segment–Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention |
title_fullStr | Prognostic Implications of Door‐to‐Balloon Time and Onset‐to‐Door Time on Mortality in Patients With ST‐Segment–Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention |
title_full_unstemmed | Prognostic Implications of Door‐to‐Balloon Time and Onset‐to‐Door Time on Mortality in Patients With ST‐Segment–Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention |
title_short | Prognostic Implications of Door‐to‐Balloon Time and Onset‐to‐Door Time on Mortality in Patients With ST‐Segment–Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention |
title_sort | prognostic implications of door‐to‐balloon time and onset‐to‐door time on mortality in patients with st‐segment–elevation myocardial infarction treated with primary percutaneous coronary intervention |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512115/ https://www.ncbi.nlm.nih.gov/pubmed/31041869 http://dx.doi.org/10.1161/JAHA.119.012188 |
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