Assessment of Blood Tumor Mutational Burden as a Potential Biomarker for Immunotherapy in Patients With Non–Small Cell Lung Cancer With Use of a Next-Generation Sequencing Cancer Gene Panel

IMPORTANCE: Tumor mutational burden (TMB), as measured by whole-exome sequencing (WES) or a cancer gene panel (CGP), is associated with immunotherapy responses. However, whether TMB estimated by circulating tumor DNA in blood (bTMB) is associated with clinical outcomes of immunotherapy remains to be...

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Detalles Bibliográficos
Autores principales: Wang, Zhijie, Duan, Jianchun, Cai, Shangli, Han, Miao, Dong, Hua, Zhao, Jun, Zhu, Bo, Wang, Shuhang, Zhuo, Minglei, Sun, Jianguo, Wang, Qiming, Bai, Hua, Han, Jiefei, Tian, Yanhua, Lu, Jing, Xu, Tongfu, Zhao, Xiaochen, Wang, Guoqiang, Cao, Xinkai, Li, Fugen, Wang, Dalei, Chen, Yuejun, Bai, Yuezong, Zhao, Jing, Zhao, Zhengyi, Zhang, Yuzi, Xiong, Lei, He, Jie, Gao, Shugeng, Wang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2019
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512308/
https://www.ncbi.nlm.nih.gov/pubmed/30816954
http://dx.doi.org/10.1001/jamaoncol.2018.7098

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