Tracking tumor evolution one-cell-at-a-time

Accumulating evidence suggests that intra-tumor heterogeneity (ITH) within tumor sub-populations is a major contributor to therapy resistance, with genomically distinct clonal populations exhibiting different therapeutic vulnerabilities. Here we employed single-cell transcriptomics in patient-derive...

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Detalles Bibliográficos
Autores principales: Sharma, Ankur, DasGupta, Ramanuj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512908/
https://www.ncbi.nlm.nih.gov/pubmed/31131309
http://dx.doi.org/10.1080/23723556.2019.1590089
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author Sharma, Ankur
DasGupta, Ramanuj
author_facet Sharma, Ankur
DasGupta, Ramanuj
author_sort Sharma, Ankur
collection PubMed
description Accumulating evidence suggests that intra-tumor heterogeneity (ITH) within tumor sub-populations is a major contributor to therapy resistance, with genomically distinct clonal populations exhibiting different therapeutic vulnerabilities. Here we employed single-cell transcriptomics in patient-derived primary cells to understand the impact of phenotypic intra-tumor heterogeneity on drug-induced tumor evolution in oral squamous cell carcinoma.
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spelling pubmed-65129082020-04-02 Tracking tumor evolution one-cell-at-a-time Sharma, Ankur DasGupta, Ramanuj Mol Cell Oncol Author's Views Accumulating evidence suggests that intra-tumor heterogeneity (ITH) within tumor sub-populations is a major contributor to therapy resistance, with genomically distinct clonal populations exhibiting different therapeutic vulnerabilities. Here we employed single-cell transcriptomics in patient-derived primary cells to understand the impact of phenotypic intra-tumor heterogeneity on drug-induced tumor evolution in oral squamous cell carcinoma. Taylor & Francis 2019-04-02 /pmc/articles/PMC6512908/ /pubmed/31131309 http://dx.doi.org/10.1080/23723556.2019.1590089 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Sharma, Ankur
DasGupta, Ramanuj
Tracking tumor evolution one-cell-at-a-time
title Tracking tumor evolution one-cell-at-a-time
title_full Tracking tumor evolution one-cell-at-a-time
title_fullStr Tracking tumor evolution one-cell-at-a-time
title_full_unstemmed Tracking tumor evolution one-cell-at-a-time
title_short Tracking tumor evolution one-cell-at-a-time
title_sort tracking tumor evolution one-cell-at-a-time
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512908/
https://www.ncbi.nlm.nih.gov/pubmed/31131309
http://dx.doi.org/10.1080/23723556.2019.1590089
work_keys_str_mv AT sharmaankur trackingtumorevolutiononecellatatime
AT dasguptaramanuj trackingtumorevolutiononecellatatime

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