Tumor growth fueled by spurious senescence phenotypes

Cancer treatments can induce a form of senescence that halts cellular division while allowing continued secretion of tumor-promoting proteins. We recently found that antiangiogenic treatment resistance can lead to a transient hijacking of the senescence-controlled secretory machinery that, when ther...

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Detalles Bibliográficos
Autores principales: Mastri, Michalis, Ebos, John M. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512925/
https://www.ncbi.nlm.nih.gov/pubmed/31131302
http://dx.doi.org/10.1080/23723556.2019.1575707
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author Mastri, Michalis
Ebos, John M. L.
author_facet Mastri, Michalis
Ebos, John M. L.
author_sort Mastri, Michalis
collection PubMed
description Cancer treatments can induce a form of senescence that halts cellular division while allowing continued secretion of tumor-promoting proteins. We recently found that antiangiogenic treatment resistance can lead to a transient hijacking of the senescence-controlled secretory machinery that, when therapeutically targeted during treatment cessation, can blunt rebound tumor growth.
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spelling pubmed-65129252020-02-20 Tumor growth fueled by spurious senescence phenotypes Mastri, Michalis Ebos, John M. L. Mol Cell Oncol Author's Views Cancer treatments can induce a form of senescence that halts cellular division while allowing continued secretion of tumor-promoting proteins. We recently found that antiangiogenic treatment resistance can lead to a transient hijacking of the senescence-controlled secretory machinery that, when therapeutically targeted during treatment cessation, can blunt rebound tumor growth. Taylor & Francis 2019-02-20 /pmc/articles/PMC6512925/ /pubmed/31131302 http://dx.doi.org/10.1080/23723556.2019.1575707 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Mastri, Michalis
Ebos, John M. L.
Tumor growth fueled by spurious senescence phenotypes
title Tumor growth fueled by spurious senescence phenotypes
title_full Tumor growth fueled by spurious senescence phenotypes
title_fullStr Tumor growth fueled by spurious senescence phenotypes
title_full_unstemmed Tumor growth fueled by spurious senescence phenotypes
title_short Tumor growth fueled by spurious senescence phenotypes
title_sort tumor growth fueled by spurious senescence phenotypes
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512925/
https://www.ncbi.nlm.nih.gov/pubmed/31131302
http://dx.doi.org/10.1080/23723556.2019.1575707
work_keys_str_mv AT mastrimichalis tumorgrowthfueledbyspurioussenescencephenotypes
AT ebosjohnml tumorgrowthfueledbyspurioussenescencephenotypes

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