TAK1 safeguards endothelial cells from gut microbes and inflammation

How endothelial cells (ECs) survive in inflammatory environments remains unclear. We recently showed that TAK1 protects ECs against apoptosis induced by TNFα under physiological conditions in the intestine and liver, and under inflammatory conditions in other organs. Our results document that a sing...

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Detalles Bibliográficos
Autores principales: Naito, Hisamichi, Takakura, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512928/
https://www.ncbi.nlm.nih.gov/pubmed/31131307
http://dx.doi.org/10.1080/23723556.2019.1588657
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author Naito, Hisamichi
Takakura, Nobuyuki
author_facet Naito, Hisamichi
Takakura, Nobuyuki
author_sort Naito, Hisamichi
collection PubMed
description How endothelial cells (ECs) survive in inflammatory environments remains unclear. We recently showed that TAK1 protects ECs against apoptosis induced by TNFα under physiological conditions in the intestine and liver, and under inflammatory conditions in other organs. Our results document that a single gene can affect cell fate decisions in mature ECs.
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spelling pubmed-65129282020-03-13 TAK1 safeguards endothelial cells from gut microbes and inflammation Naito, Hisamichi Takakura, Nobuyuki Mol Cell Oncol Author's Views How endothelial cells (ECs) survive in inflammatory environments remains unclear. We recently showed that TAK1 protects ECs against apoptosis induced by TNFα under physiological conditions in the intestine and liver, and under inflammatory conditions in other organs. Our results document that a single gene can affect cell fate decisions in mature ECs. Taylor & Francis 2019-03-13 /pmc/articles/PMC6512928/ /pubmed/31131307 http://dx.doi.org/10.1080/23723556.2019.1588657 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Naito, Hisamichi
Takakura, Nobuyuki
TAK1 safeguards endothelial cells from gut microbes and inflammation
title TAK1 safeguards endothelial cells from gut microbes and inflammation
title_full TAK1 safeguards endothelial cells from gut microbes and inflammation
title_fullStr TAK1 safeguards endothelial cells from gut microbes and inflammation
title_full_unstemmed TAK1 safeguards endothelial cells from gut microbes and inflammation
title_short TAK1 safeguards endothelial cells from gut microbes and inflammation
title_sort tak1 safeguards endothelial cells from gut microbes and inflammation
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512928/
https://www.ncbi.nlm.nih.gov/pubmed/31131307
http://dx.doi.org/10.1080/23723556.2019.1588657
work_keys_str_mv AT naitohisamichi tak1safeguardsendothelialcellsfromgutmicrobesandinflammation
AT takakuranobuyuki tak1safeguardsendothelialcellsfromgutmicrobesandinflammation

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