Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid

Our recently published study uncovered mechanisms and prognostic impact of aberrant DNA methylation/hydroxymethylation in clear cell renal cell carcinoma, and comprehensively explored the potential of Ascorbic acid in reversing the epigenetic aberrancy. This article provides a summary of the finding...

Descripción completa

Detalles Bibliográficos
Autor principal: Shenoy, Niraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512931/
https://www.ncbi.nlm.nih.gov/pubmed/31131312
http://dx.doi.org/10.1080/23723556.2019.1595309
_version_ 1783417709161086976
author Shenoy, Niraj
author_facet Shenoy, Niraj
author_sort Shenoy, Niraj
collection PubMed
description Our recently published study uncovered mechanisms and prognostic impact of aberrant DNA methylation/hydroxymethylation in clear cell renal cell carcinoma, and comprehensively explored the potential of Ascorbic acid in reversing the epigenetic aberrancy. This article provides a summary of the findings and their translational significance, and important considerations while testing Ascorbic acid as an anti-cancer agent. Abbreviations- ccRCC: clear cell renal cell carcinoma; TET: Ten-Eleven Translocation; 5mC: 5-methylcytosine; 5hmC: 5-hydroxymethylcytosine; L2HG: l-2-hydroxyglutarate; L2HGDH: l-2-hydroxyglutarate dehydrogenase; 2-OG: 2-Oxoglutarate; AA: Ascorbic acid
format Online
Article
Text
id pubmed-6512931
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-65129312020-04-03 Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid Shenoy, Niraj Mol Cell Oncol Author's Views Our recently published study uncovered mechanisms and prognostic impact of aberrant DNA methylation/hydroxymethylation in clear cell renal cell carcinoma, and comprehensively explored the potential of Ascorbic acid in reversing the epigenetic aberrancy. This article provides a summary of the findings and their translational significance, and important considerations while testing Ascorbic acid as an anti-cancer agent. Abbreviations- ccRCC: clear cell renal cell carcinoma; TET: Ten-Eleven Translocation; 5mC: 5-methylcytosine; 5hmC: 5-hydroxymethylcytosine; L2HG: l-2-hydroxyglutarate; L2HGDH: l-2-hydroxyglutarate dehydrogenase; 2-OG: 2-Oxoglutarate; AA: Ascorbic acid Taylor & Francis 2019-04-03 /pmc/articles/PMC6512931/ /pubmed/31131312 http://dx.doi.org/10.1080/23723556.2019.1595309 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Shenoy, Niraj
Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid
title Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid
title_full Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid
title_fullStr Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid
title_full_unstemmed Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid
title_short Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid
title_sort epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with ascorbic acid
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512931/
https://www.ncbi.nlm.nih.gov/pubmed/31131312
http://dx.doi.org/10.1080/23723556.2019.1595309
work_keys_str_mv AT shenoyniraj epigeneticdysregulationbyaberrantmetabolisminrenalcellcarcinomacanbereversedwithascorbicacid

Ejemplares similares