Mechano-regulation of proline metabolism and cancer progression by kindlin-2

Alterations of cell mechano-environment and metabolism are common features of malignant neoplasm. We recently showed that increased stiffness of extracellular matrix is intrinsically linked to up-regulation of proline synthesis through a mechano-responsive fermitin family homolog 2 (FERMT2, best kno...

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Detalles Bibliográficos
Autores principales: Guo, Ling, Wu, Chuanyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author';s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512932/
https://www.ncbi.nlm.nih.gov/pubmed/31131313
http://dx.doi.org/10.1080/23723556.2019.1596003
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author Guo, Ling
Wu, Chuanyue
author_facet Guo, Ling
Wu, Chuanyue
author_sort Guo, Ling
collection PubMed
description Alterations of cell mechano-environment and metabolism are common features of malignant neoplasm. We recently showed that increased stiffness of extracellular matrix is intrinsically linked to up-regulation of proline synthesis through a mechano-responsive fermitin family homolog 2 (FERMT2, best known as kindlin-2) and pyrroline-5-carboxylate reductase 1(PYCR1) complex, which in turn promotes collagen matrix synthesis, cell proliferation, survival, and cancer progression.
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spelling pubmed-65129322020-04-12 Mechano-regulation of proline metabolism and cancer progression by kindlin-2 Guo, Ling Wu, Chuanyue Mol Cell Oncol Author';s Views Alterations of cell mechano-environment and metabolism are common features of malignant neoplasm. We recently showed that increased stiffness of extracellular matrix is intrinsically linked to up-regulation of proline synthesis through a mechano-responsive fermitin family homolog 2 (FERMT2, best known as kindlin-2) and pyrroline-5-carboxylate reductase 1(PYCR1) complex, which in turn promotes collagen matrix synthesis, cell proliferation, survival, and cancer progression. Taylor & Francis 2019-04-12 /pmc/articles/PMC6512932/ /pubmed/31131313 http://dx.doi.org/10.1080/23723556.2019.1596003 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author';s Views
Guo, Ling
Wu, Chuanyue
Mechano-regulation of proline metabolism and cancer progression by kindlin-2
title Mechano-regulation of proline metabolism and cancer progression by kindlin-2
title_full Mechano-regulation of proline metabolism and cancer progression by kindlin-2
title_fullStr Mechano-regulation of proline metabolism and cancer progression by kindlin-2
title_full_unstemmed Mechano-regulation of proline metabolism and cancer progression by kindlin-2
title_short Mechano-regulation of proline metabolism and cancer progression by kindlin-2
title_sort mechano-regulation of proline metabolism and cancer progression by kindlin-2
topic Author';s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512932/
https://www.ncbi.nlm.nih.gov/pubmed/31131313
http://dx.doi.org/10.1080/23723556.2019.1596003
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AT wuchuanyue mechanoregulationofprolinemetabolismandcancerprogressionbykindlin2

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