Dephosphorylation of the Atg1 kinase complex by type 2C protein phosphatases

In budding yeast, Atg1 kinase, together with Atg13 and Atg17, forms a complex that is essential for autophagy. Previous work showed that the Atg1 kinase complex is regulated extensively by phosphorylations. Our recent paper demonstrates that type 2C protein phosphatases Ptc2 and Ptc3 are involved in...

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Autores principales: Memisoglu, Gonen, Haber, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512942/
https://www.ncbi.nlm.nih.gov/pubmed/31131308
http://dx.doi.org/10.1080/23723556.2019.1588658
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author Memisoglu, Gonen
Haber, James E.
author_facet Memisoglu, Gonen
Haber, James E.
author_sort Memisoglu, Gonen
collection PubMed
description In budding yeast, Atg1 kinase, together with Atg13 and Atg17, forms a complex that is essential for autophagy. Previous work showed that the Atg1 kinase complex is regulated extensively by phosphorylations. Our recent paper demonstrates that type 2C protein phosphatases Ptc2 and Ptc3 are involved in the dephosphorylation of Atg13 and Atg1 kinase to promote autophagy.
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spelling pubmed-65129422020-04-08 Dephosphorylation of the Atg1 kinase complex by type 2C protein phosphatases Memisoglu, Gonen Haber, James E. Mol Cell Oncol Author's Views In budding yeast, Atg1 kinase, together with Atg13 and Atg17, forms a complex that is essential for autophagy. Previous work showed that the Atg1 kinase complex is regulated extensively by phosphorylations. Our recent paper demonstrates that type 2C protein phosphatases Ptc2 and Ptc3 are involved in the dephosphorylation of Atg13 and Atg1 kinase to promote autophagy. Taylor & Francis 2019-04-08 /pmc/articles/PMC6512942/ /pubmed/31131308 http://dx.doi.org/10.1080/23723556.2019.1588658 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Memisoglu, Gonen
Haber, James E.
Dephosphorylation of the Atg1 kinase complex by type 2C protein phosphatases
title Dephosphorylation of the Atg1 kinase complex by type 2C protein phosphatases
title_full Dephosphorylation of the Atg1 kinase complex by type 2C protein phosphatases
title_fullStr Dephosphorylation of the Atg1 kinase complex by type 2C protein phosphatases
title_full_unstemmed Dephosphorylation of the Atg1 kinase complex by type 2C protein phosphatases
title_short Dephosphorylation of the Atg1 kinase complex by type 2C protein phosphatases
title_sort dephosphorylation of the atg1 kinase complex by type 2c protein phosphatases
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512942/
https://www.ncbi.nlm.nih.gov/pubmed/31131308
http://dx.doi.org/10.1080/23723556.2019.1588658
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