The expanding landscape of ‘oncohistone’ mutations in human cancers

Mutations in epigenetic pathways are common oncogenic drivers. Histones, the fundamental substrate for chromatin-modifying and remodeling enzymes, are mutated in tumors including in gliomas, sarcomas, head and neck cancers, and carcinosarcomas. Classical ‘oncohistone’ mutations occur in the N-termin...

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Detalles Bibliográficos
Autores principales: Nacev, Benjamin A., Feng, Lijuan, Bagert, John D., Lemiesz, Agata E., Gao, JianJiong, Soshnev, Alexey, Kundra, Ritika, Schultz, Nikolaus, Muir, Tom W., Allis, C. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512987/
https://www.ncbi.nlm.nih.gov/pubmed/30894748
http://dx.doi.org/10.1038/s41586-019-1038-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512987/
https://www.ncbi.nlm.nih.gov/pubmed/30894748
http://dx.doi.org/10.1038/s41586-019-1038-1

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