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The expanding landscape of ‘oncohistone’ mutations in human cancers
Mutations in epigenetic pathways are common oncogenic drivers. Histones, the fundamental substrate for chromatin-modifying and remodeling enzymes, are mutated in tumors including in gliomas, sarcomas, head and neck cancers, and carcinosarcomas. Classical ‘oncohistone’ mutations occur in the N-termin...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512987/ https://www.ncbi.nlm.nih.gov/pubmed/30894748 http://dx.doi.org/10.1038/s41586-019-1038-1 |