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Valsartan impedes epinephrine-induced ICAM-4 activation on normal, sickle cell trait and sickle cell disease red blood cells

Abnormal red blood cell (RBC) adhesion to endothelial αvβ3 plays a crucial role in triggering vaso-occlusive episodes in sickle cell disease (SCD). It is known that epinephrine, a β-adrenergic receptor (β-AR) stimulator, increases the RBC surface density of active intercellular adhesion molecule-4 (...

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Detalles Bibliográficos
Autores principales:	Zhang, Jing, Jones, Sasia-Marie, Lykotrafitis, George, Andemariam, Biree
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513067/ https://www.ncbi.nlm.nih.gov/pubmed/31083675 http://dx.doi.org/10.1371/journal.pone.0216467

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